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New treatment option for Stroke
Official title High-definition Transcranial Electrical Stimulation for Upper Extremity Rehabilitation
ClinicalTrials.gov ID: NCT06409143
What this study is testing
- What it's testing
- Upper limb hemiparesis is the most common sequelae in patients, severely impacting their independence and quality of life. Transcranial electrical stimulation (tCES) is a non-invasive and safe treatment, which uses a low direct current or alternating current to change the excitability of the cerebral cortex.
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older. Healthy volunteers may be eligible.
You may be able to join if
- \- Sub-Project 1 (Healthy)
- Adults aged 18 and above.
- Confirmed right-handedness using the Edinburgh Handedness Inventory. Sub-Project 1 (Post-stroke patients)
- Aged 18 and above.
- Diagnosed with stroke.
You likely can't join if
- \- Sub-Project 1 (Healthy)
- History of neurological disorders (e.g., stroke, brain tumor, epilepsy), psychiatric disorders (e.g., substance abuse, major depression...
- Contraindications to transcranial electrical stimulation, including history of epilepsy, atrial fibrillation, presence of metal implants, cardiac...
- Skin allergies, contact dermatitis, abnormal pain, hypersensitivity to pain, wounds, or ulcers on the head.
- Participation in other invasive or non-invasive brain stimulation research studies.
- Pregnancy or lactating women. (If female, must be postmenopausal or surgically sterilized. Fertile women must have a negative pregnancy test result...
See the full eligibility criteria
Who can join
- \- Sub-Project 1 (Healthy)
- Adults aged 18 and above.
- Confirmed right-handedness using the Edinburgh Handedness Inventory. Sub-Project 1 (Post-stroke patients)
- Aged 18 and above.
- Diagnosed with stroke.
- Post-stroke for more than 6 months.
- Unilateral hemiparesis. Sub-Project 2 (Subacute-stroke patients)
- Aged 18 and above.
- Diagnosed with stroke.
- Stroke occurred between 7 days to 6 months ago.
- Unilateral hemiparesis.
- Degree of recovery for proximal and distal movements of the affected upper limb is Brunnstrom stage III to V.
- No severe muscle spasticity in any segments of the affected upper limb (Modified Ashworth Scale ≤ 2).
What rules you out
- \- Sub-Project 1 (Healthy)
- History of neurological disorders (e.g., stroke, brain tumor, epilepsy), psychiatric disorders (e.g., substance abuse, major depression, schizophrenia, bipolar disorder), or musculoskeletal disorders of the upper limb.
- Contraindications to transcranial electrical stimulation, including history of epilepsy, atrial fibrillation, presence of metal implants, cardiac pacemakers, convexity skull defects, or increased intracranial pressure.
- Skin allergies, contact dermatitis, abnormal pain, hypersensitivity to pain, wounds, or ulcers on the head.
- Participation in other invasive or non-invasive brain stimulation research studies.
- Pregnancy or lactating women. (If female, must be postmenopausal or surgically sterilized. Fertile women must have a negative pregnancy test result. Fertile female patients engaging in heterosexual intercourse, as well...
- History of alcohol or substance abuse.
- Damaged skin at the stimulation site, electrode contact, or device wearing site.
- Long-term use of central nervous system affecting medications (such as antidepressants, sedatives) or other medications that may affect seizure threshold.
- Other conditions deemed unsuitable for transcranial electrical or magnetic stimulation by a physician.
- Affiliation with any research institution/execution unit (e.g., students from NTU, Taipei Medical University). Sub-Project 1 (Post-stroke patients)
- Contraindications to transcranial electrical stimulation include a history of epilepsy, atrial fibrillation, presence of metal implants, cardiac pacemakers, convexity skull defects, or increased intracranial pressure.
- Skin allergies, contact dermatitis, abnormal pain, hypersensitivity to pain, wounds, or ulcers on the head.
- Severe neurological or psychiatric disorders other than stroke (such as major depression, schizophrenia, substance abuse, organic brain diseases, Parkinson's disease, brain tumors).
- Use of medications that may lower the seizure threshold.
- Undergoing other invasive or non-invasive brain stimulation therapies.
- Pregnancy or lactating women. (If female, must be postmenopausal or surgically sterilized. Fertile women must have a negative pregnancy test result. Fertile female patients engaging in heterosexual intercourse, as well...
- History of alcohol or substance abuse.
- Damaged skin at the stimulation site, electrode contact, or device wearing site.
- Long-term use of central nervous system affecting medications (such as antidepressants, sedatives) or other medications that may affect seizure threshold.
- Other conditions deemed unsuitable for transcranial electrical or magnetic stimulation by a physician. Sub-Project 2 (Subacute-stroke patients)
- Contraindications to transcranial electrical stimulation include a history of epilepsy, atrial fibrillation, presence of metal implants, cardiac pacemakers, convexity skull defects, or increased intracranial pressure.
- Skin allergies, contact dermatitis, abnormal pain, hypersensitivity to pain, wounds, or ulcers on the head.
- Severe neurological or psychiatric disorders other than stroke (such as major depression, schizophrenia, substance abuse, organic brain diseases, Parkinson's disease, brain tumors).
- Use of medications that may lower the seizure threshold.
- Other muscle and joint problems affecting upper limb function, such as joint contractures, rheumatoid arthritis, myositis ossificans.
- Severe cognitive impairment or receptive or global aphasia making it difficult to understand instructions.
- Hemineglect (including visual, auditory, or sensory neglect).
- Undergoing other invasive or non-invasive brain stimulation therapies.
- Pregnancy or lactating women. (If female, must be postmenopausal or surgically sterilized. Fertile women must have a negative pregnancy test result. Fertile female patients engaging in heterosexual intercourse, as well...
- History of alcohol or substance abuse.
- Damaged skin at the stimulation site, electrode contact, or device wearing site.
- Long-term use of central nervous system affecting medications (such as antidepressants, sedatives) or other medications that may affect seizure threshold.
- Other conditions deemed unsuitable for transcranial electrical or magnetic stimulation by a physician.
The study team makes the final eligibility decision.
Where it's taking place
- New Taipei City, Taiwan
- Taipei, Taiwan
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include New Taipei City, Taiwan; Taipei, Taiwan. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.