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New treatment option for Plexus Choroideus
Official title Choroid Plexus Dysfunction in Neurological Diseases
ClinicalTrials.gov ID: NCT06403189
What this study is testing
- What it's testing
- Cerebral folate deficiency (CFD), a partially treatable condition defined by a low folate cerebrospinal fluid (CSF) concentration, can be linked to genetic defects of folate metabolism or be secondary to various diseases without clear causal link. The team identified a neurological syndrome (named LHIPFOLFD) characterized by deep CFD and a specific leukoencephalopathy, related to several possible gene defects never involving folate metabolism.
- Time commitment: about 2 years
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older. Healthy volunteers may be eligible.
You may be able to join if
- For LHIPFOLD patients:
- Suspicion of diagnosis or diagnosis of LHIPFOLD syndrome documented in the medical record, i.e. presence of these three manifestations: severe...
- Patient covered by Social Security or Complementary Health Insurance or any equivalent scheme (including AME). For Neurological Controls (NC) :
- No chronic pathology (notably no renal, cardiac, pulmonary or hepatic disease)
- Patients with one of the following neurological pathologies (confirmed diagnosis or strong suspicion), investigated in the course of routine clinical...
You likely can't join if
- For all research participants:
- Age \<18
- Pregnant and breast-feeding women.
- Participant unable to give informed consent.
- Participant with a contraindication to MRI: implantable cardiac defibrillators, prostheses, transdermal patches, catheters; implantable pumps...
- Participants with contraindications to contrast injection: known allergy to gadolinium chelates, severe renal insufficiency, pregnancy (BHCG for...
See the full eligibility criteria
- For LHIPFOLD patients:
- Suspicion of diagnosis or diagnosis of LHIPFOLD syndrome documented in the medical record, i.e. presence of these three manifestations: severe intrathecal deficiency in 5MTHF\ 1 g/L, and white matter abnormalities on...
- Patient covered by Social Security or Complementary Health Insurance or any equivalent scheme (including AME). For Neurological Controls (NC) :
- No chronic pathology (notably no renal, cardiac, pulmonary or hepatic disease)
- Patients with one of the following neurological pathologies (confirmed diagnosis or strong suspicion), investigated in the course of routine clinical practice: Alzheimer's disease, multiple sclerosis, amyotrophic...
- No chronic pathology (in particular, no renal, cardiac, pulmonary, hepatic or psychiatric disease)
- No history of neurological pathology
- No chronic alcohol intoxication
- No consumption of toxic substances in the week preceding the inclusion visit
- No neurological or psychotropic medication.
- For all research participants:
- Age \<18
- Pregnant and breast-feeding women.
- Participant unable to give informed consent.
- Participant with a contraindication to MRI: implantable cardiac defibrillators, prostheses, transdermal patches, catheters; implantable pumps; artificial heart valves; implants to treat deafness (if incompatible with...
- Participants with contraindications to contrast injection: known allergy to gadolinium chelates, severe renal insufficiency, pregnancy (BHCG for women of childbearing age prior to MRI), breast-feeding.
- Participants with contraindications to LP: haemostasis abnormalities (PT\<50%, platelets \< 40\ 109/L), mass syndrome on brain imaging, suspected infection at or near the needle insertion site, coagulopathy...
- Participant under legal protection (guardianship, curatorship)
- Participant not covered by Social Security or Complementary Health Insurance or any equivalent scheme (excluding AME).
- Taking folate, vitamin C or dietary supplements containing vitamins (excluding vitamin D and E) in the two months prior to inclusion.
The study team makes the final eligibility decision.
Where it's taking place
- Paris, France
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The study runs about 2 years per participant, based on its public description. The team confirms the exact schedule and number of visits before you enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Paris, France. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.