BridgeMD
New treatment option for Stroke, Acute Ischemic
Official title Endovascular Treatment for eXtra-Large Ischemic Stroke
ClinicalTrials.gov ID: NCT06388148
What this study is testing
What is Medical management?
Medical management is an investigational medicine, given as an infusion into a vein, being studied as a potential treatment for stroke, acute ischemic.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- The role of endovascular thrombectomy in patients with extra-large ischemic burden is still unclear. The XL STROKE-2 randomized trial is aiming to investigate the efficacy and safety of mechanical thrombectomy in acute extra-large ischemic stroke patients with large vessel occlusion.
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Age 18 years or older, and modified Rankin scale score = 0 or 1 in patients 80 years or older;
- Acute ischemic stroke within 6 hours from last known well to randomization, or with negative MRI-FLAIR (no change on FLAIR sequence and presence of...
- Occlusion of the internal carotid artery, M1 or M2 segment of the middle cerebral artery confirmed by CTA/MRA/DSA;
- Baseline ASPECTS score of 0-2 or infarct core volume ≥100ml;
- The patient or patient's representative signs a written informed consent form.
You likely can't join if
- CT or MR evidence of hemorrhage;
- Evidence of mass effect with ventricular effacement, midline shift or herniation on baseline imaging;
- Vessel tortuosity where it is expected that the thrombectomy device will not be able to reach the occlusion site or result in unstable access;
- History of bleeding disorders, severe heart, liver or kidney disease, or sepsis;
- Currently participating in another investigational drug study;
- Any terminal illness with life expectancy less than 6 months.
The study team makes the final eligibility decision.
Where it's taking place
- Hengyang, Hunan, China
- Xiangtan, Hunan, China
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Hengyang, Hunan, China; Xiangtan, Hunan, China. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.