BridgeMD
New treatment option for Depression
Official title Mechanisms Underlying Antidepressant Effects of Physical Activity
ClinicalTrials.gov ID: NCT06387732
What this study is testing
- What it's testing
- It is well established that any level of physical activity can help prevent and treat depression, with more strenuous activity having a greater effect. Understanding the mechanisms driving this antidepressant effect is important because it could allow exercise programmes to be made more effective, accessible, and targeted.
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 60. Healthy volunteers may be eligible.
You may be able to join if
- will include:
- PHQ9≥12 (moderate depression).
- Current physical activity level below 30 min moderate physical activity, once per week.
- Fluency in English.
- Willingness to undergo the interventions.
You likely can't join if
- will include:
- Medical contraindications to either intervention.
- Neurological illness.
- Past or current diagnosis of psychosis, bipolar disorder, or substance/alcohol use disorder, unless restricted to a depressive episode.
- Unable to complete self-administered cognitive or questionnaire assessments.
- Symptoms or cognitive impairment that would limit capacity to consent.
See the full eligibility criteria
- will include:
- PHQ9≥12 (moderate depression).
- Current physical activity level below 30 min moderate physical activity, once per week.
- Fluency in English.
- Willingness to undergo the interventions.
- Age 18-60.
- Willing and able to provide written informed consent.
- will include:
- Medical contraindications to either intervention.
- Neurological illness.
- Past or current diagnosis of psychosis, bipolar disorder, or substance/alcohol use disorder, unless restricted to a depressive episode.
- Unable to complete self-administered cognitive or questionnaire assessments.
- Symptoms or cognitive impairment that would limit capacity to consent.
- Pregnancy.
- Regular use of anti-inflammatory medication (more than once per week).
The study team makes the final eligibility decision.
Where it's taking place
- London, United Kingdom
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 60 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include London, United Kingdom. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.