BridgeMD
New treatment option for Overactive Bladder
Official title Bladder Botox UTI Antibiotic Prophylaxis
ClinicalTrials.gov ID: NCT06387329
What this study is testing
What is Nitrofurantoin 100 MG?
Nitrofurantoin 100 MG is an investigational medicine, given as an once-daily infusion into a vein, being studied as a potential treatment for overactive bladder.
Also referred to as Macrobid.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- Overactive bladder (OAB) is a common condition with a prevalence of 17% in the general population that significantly affects quality of life. Intradetrusor onabotulinumtoxinA injections are an advanced therapy for OAB as well as interstitial cystitis/bladder pain syndrome (IC/BPS).
- Phase 4: studies an already-approved treatment
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older. Healthy volunteers may be eligible.
You may be able to join if
- All patients 18 years or older being seen at the WRNMMC Urogynecology clinic
- Diagnosis of OAB or IC/BPS
- Planning to undergo intradetrusor onabotulinumtoxinA injection for treatment of their OAB or IC/BPS
- Ability to follow instructions and complete follow up
You likely can't join if
- Contraindication to nitrofurantoin (allergy, CrCl \<30mL/minute)
- If performed in the operating room, the patient cannot undergo a concurrent procedure that would increase the risk of UTI or require an alternate...
- Active UTI at the time of procedure
- Neurogenic bladder
- Recurrent UTI (3 in 12 month period or 2 in 6 months)
- Post void residual bladder volume ≥150mL
See the full eligibility criteria
- All patients 18 years or older being seen at the WRNMMC Urogynecology clinic
- Diagnosis of OAB or IC/BPS
- Planning to undergo intradetrusor onabotulinumtoxinA injection for treatment of their OAB or IC/BPS
- Ability to follow instructions and complete follow up
- Contraindication to nitrofurantoin (allergy, CrCl \<30mL/minute)
- If performed in the operating room, the patient cannot undergo a concurrent procedure that would increase the risk of UTI or require an alternate antibiotic regimen (such as hysterectomy, prolapse repair, or...
- Active UTI at the time of procedure
- Neurogenic bladder
- Recurrent UTI (3 in 12 month period or 2 in 6 months)
- Post void residual bladder volume ≥150mL
- Patient is already taking antibiotics at the time of the procedure
- Contraindication to onabotulinumtoxinA (allergy, pregnancy, greater than 400 units of onabotulinumtoxinA received in the last 3 months)
The study team makes the final eligibility decision.
Where it's taking place
- Bethesda, Maryland, United States
Compensation & support
A stipend or compensation may be offered.
Compensation mentioned.
ClinicalTrials.gov doesn't provide a reliable structured field for payment or travel support - confirm details with the study team.
Questions & answers
Do participants get paid in this trial?
This study's listing includes signals that participants may be compensated or receive a stipend. Amounts vary and are set by the study team - confirm the details with them.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Bethesda, Maryland, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.