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New treatment option for Thiazide Associated Hyponatremia
Official title Validation of New Diagnostic Indices to Simplify Hyponatremia Therapy Assessment in Patients on Thiazide Diuretics
ClinicalTrials.gov ID: NCT06381934
What this study is testing
- What it's testing
- This study is looking at two new parameters, aSID and ChU, to see if these can help physicians to distinguish between different causes of low sodium levels (hyponatremia) in Patients taking a medicament against high blood pressure (thiazide). Researchers also want to see if using these new parameters to decide on treatment works just as well, or better, than the current standard treatments.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Hospitalized patients presenting at University Hospital Basel
- aged 18 years or older
- able to give informed consent as documented by signature
- with serum sodium level \< 133 mmol/l and serum osmolality \< 300 mOsm/kg
- with treatment with thiazide or thiazide-like diuretic
You likely can't join if
- symptomatic hyponatremia in need of 3% hypertonic solution or intensive care treatment
- inability or contraindications to undergo the trial (i.e., any acute severe cardiovascular event requiring an immediate intervention)
- decompensated liver cirrhosis CHILD C
- decompensated heart failure NYHA III or higher
- severe valve impairment
- untreated adrenal insufficiency
See the full eligibility criteria
- Hospitalized patients presenting at University Hospital Basel
- aged 18 years or older
- able to give informed consent as documented by signature
- with serum sodium level \< 133 mmol/l and serum osmolality \< 300 mOsm/kg
- with treatment with thiazide or thiazide-like diuretic
- symptomatic hyponatremia in need of 3% hypertonic solution or intensive care treatment
- inability or contraindications to undergo the trial (i.e., any acute severe cardiovascular event requiring an immediate intervention)
- decompensated liver cirrhosis CHILD C
- decompensated heart failure NYHA III or higher
- severe valve impairment
- untreated adrenal insufficiency
- severe kidney disease in need of dialysis
- pregnancy or breastfeeding
- end of life care
- inability to follow the study procedures (i.e., language problem, dementia or critical illness).
The study team makes the final eligibility decision.
Where it's taking place
- Basel, Switzerland
Compensation & support
A stipend or compensation may be offered.
Compensation mentioned.
ClinicalTrials.gov doesn't provide a reliable structured field for payment or travel support - confirm details with the study team.
Questions & answers
Do participants get paid in this trial?
This study's listing includes signals that participants may be compensated or receive a stipend. Amounts vary and are set by the study team - confirm the details with them.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Basel, Switzerland. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.