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Compares treatment options for Burns
Official title Burn Study- Tranexamic Acid Versus Thrombin in Split Thickness Skin Graft
ClinicalTrials.gov ID: NCT06379724
What this study is testing
What is Tranexamic acid?
Tranexamic acid is an investigational medicine, given as a treatment applied to the skin, being studied as a potential treatment for burns.
Also referred to as TXA.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- Investigators hypothesize that topical tranexamic acid will have better or comparable efficacy to topical thrombin in reducing hematoma formation at the wound base. The purpose of the study is to demonstrate that topical tranexamic acid will be a non-inferior alternative medication to the current standard of care,THROMBIN-JMI® , and at a lower cost to the health system.
- Phase 4: studies an already-approved treatment
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- English or Spanish speaking
- Flame or scald burn injury
- \<=10% total body surface area (TBSA) partial thickness
- \<= 5% total body surface area (TBSA) deep partial or full thickness
- Skin graft harvested at 1/12 inch depth, meshed 1:1 or pie crusted if the area is a small functional area
You likely can't join if
- \>10% total body surface area (TBSA) partial thickness burn
- \>5% total body surface area (TBSA )surgical area of burn injury (deep partial or full thickness injury)
- Traumatic or chemical burn mechanism
- Patients on immunosuppression
- Uncontrolled diabetes
- Known diagnosis of peripheral vascular disease or diagnosis at time of injury
See the full eligibility criteria
- English or Spanish speaking
- Flame or scald burn injury
- \<=10% total body surface area (TBSA) partial thickness
- \<= 5% total body surface area (TBSA) deep partial or full thickness
- Skin graft harvested at 1/12 inch depth, meshed 1:1 or pie crusted if the area is a small functional area
- \>10% total body surface area (TBSA) partial thickness burn
- \>5% total body surface area (TBSA )surgical area of burn injury (deep partial or full thickness injury)
- Traumatic or chemical burn mechanism
- Patients on immunosuppression
- Uncontrolled diabetes
- Known diagnosis of peripheral vascular disease or diagnosis at time of injury
- Pregnant women
- Patients with acquired defective color vision
- Patients with subarachnoid hemorrhage
- Patients with active intravascular clotting or known hypersensitivity reactions to tranexamic acid
- Inability to give informed consent
The study team makes the final eligibility decision.
Where it's taking place
- Kansas City, Kansas, United States
Compensation & support
Compensation mentioned.
ClinicalTrials.gov doesn't provide a reliable structured field for payment or travel support - confirm details with the study team.
Questions & answers
Do participants get paid in this trial?
This study's listing includes signals that participants may be compensated or receive a stipend. Amounts vary and are set by the study team - confirm the details with them.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Kansas City, Kansas, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.