BridgeMD
New treatment option for Sedentary Behavior
Official title Multi-organ Responses to CHronic Physical Activity and INactivity
ClinicalTrials.gov ID: NCT06377254
What this study is testing
- What it's testing
- Life expectancy has been increasing for the last 150 years, but the maintenance of health has not kept pace with increased lifespan, and on average, UK adults spend the last decade of life in poor-health, with major consequences for society and the individual. Persistent physical inactivity is thought to be a key contributing factor to the risk of poor health and functional decline occurring in middle-aged and older adults.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 50 to 65. Healthy volunteers may be eligible.
You may be able to join if
- Group 1 ('non-sedentary') self-reporting \ 8,000 steps/day).
- Group 2 ('sedentary') self-reporting ≥8 waking hrs/day in sedentary activities and/or ≤5,000 steps/day.
- Aged 50-65y.
- Overweight (BMI 25-35 kg/m2).
- Waist circumference ≥94cm (males) and ≥80cm (females).
You likely can't join if
- Regular medication use that could interfere with measures
- A history, or evidence, of chronic cardiovascular, metabolic, musculoskeletal, renal or respiratory diseases.
- Experiencing 'long-COVID', inflammatory bowel disease or malignancy.
- Uncontrolled hypertension. Stage 1 hypertension (BP ≤160/100mmHg) with no other signs of cardiovascular disease, and blood pressure (BP) managed by...
- People employed in jobs that would preclude reducing step count and night-shift workers.
- Females who are pre/peri-menopausal, (due to effect of oestrogen fluctuations on primary outcomes and the longitudinal study design), but individuals...
See the full eligibility criteria
- Group 1 ('non-sedentary') self-reporting \ 8,000 steps/day).
- Group 2 ('sedentary') self-reporting ≥8 waking hrs/day in sedentary activities and/or ≤5,000 steps/day.
- Aged 50-65y.
- Overweight (BMI 25-35 kg/m2).
- Waist circumference ≥94cm (males) and ≥80cm (females).
- Willing to alter physical activity levels as instructed for 6 months
- Without neurological or psychiatric diseases, motor or cognitive restrictions
- Ability to give informed consent
- Regular medication use that could interfere with measures
- A history, or evidence, of chronic cardiovascular, metabolic, musculoskeletal, renal or respiratory diseases.
- Experiencing 'long-COVID', inflammatory bowel disease or malignancy.
- Uncontrolled hypertension. Stage 1 hypertension (BP ≤160/100mmHg) with no other signs of cardiovascular disease, and blood pressure (BP) managed by routine medication will not be an exclusion.
- People employed in jobs that would preclude reducing step count and night-shift workers.
- Females who are pre/peri-menopausal, (due to effect of oestrogen fluctuations on primary outcomes and the longitudinal study design), but individuals stable on hormone replacement therapy are eligible.
- Contraindications for MRI.
- Allergy or sensitivity to local anaesthesia, or dressing adhesive
The study team makes the final eligibility decision.
Where it's taking place
- Nottingham, Notts, United Kingdom
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 50 years to 65 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Nottingham, Notts, United Kingdom. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.