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Compares treatment options for Ventricular Tachycardia
Official title Radiotherapy vs Catheter Ablation for Ventricular Tachycardia in Structural Heart Disease
ClinicalTrials.gov ID: NCT06360939
What this study is testing
- What it's testing
- The goal of this randomized clinical trial is to test the efficacy of stereotactic body radiation therapy (SBRT) in treating ventricular tachycardia (VT) in patients with advanced structural heart disease. The main questions it aims to answer are: What is the efficacy of SBRT compared to catheter ablation (CA) in achieving a ≥ 75% reduction in VT burden at 6 months What is the comparable safety profile of SBRT vs CA Researchers will compare SBRT and CA (standard of care).
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Structural heart disease (including ischaemic cardiomyopathy , non-ischaemic cardiomyopathy or congenital heart disease and defined as any one of
- segmental or global decreased ventricular wall motion as defined by TTE, CT or cMRI
- myocardial hypertrophy
- myocardial scar (evidenced by late gadolinium enhancement on cMRI, wall thinning on cardiac CT, low voltage on electrophysiological study or abnormal...
- Recurrent monomorphic VT which can include
You likely can't join if
- Age \< 18 years
- Life expectancy \< 3 months
- Catheter ablation deemed futile or with prohibitive risk by cardiac electrophysiologist.
- Unwilling or unable to provide consent
- Known cardiac channelopathies (e.g. Catecholaminergic polymorphic ventricular tachycardia (CPVT), long- or short QT syndrome, Brugada syndrome)
- Contraindications to radiotherapy as deemed by referring physician and/or radiation oncologist
See the full eligibility criteria
- Structural heart disease (including ischaemic cardiomyopathy , non-ischaemic cardiomyopathy or congenital heart disease and defined as any one of
- segmental or global decreased ventricular wall motion as defined by TTE, CT or cMRI
- myocardial hypertrophy
- myocardial scar (evidenced by late gadolinium enhancement on cMRI, wall thinning on cardiac CT, low voltage on electrophysiological study or abnormal intracardiac echocardiography)
- Recurrent monomorphic VT which can include
- at least one episode of VT treated by ICD and/or
- sustained VT (lasting \>30s) and/or
- inducible sustained VT on invasive electrophysiological study (EPS) or non-invasive programmed stimulation (NIPS)
- PAINESD score of ≥9 points and/or at least moderate risk of VT recurrence or death as defined by the I-VT score. Both are validated tools used clinically to identify patient at high risk of VT recurrence and/or...
- Age \< 18 years
- Life expectancy \< 3 months
- Catheter ablation deemed futile or with prohibitive risk by cardiac electrophysiologist.
- Unwilling or unable to provide consent
- Known cardiac channelopathies (e.g. Catecholaminergic polymorphic ventricular tachycardia (CPVT), long- or short QT syndrome, Brugada syndrome)
- Contraindications to radiotherapy as deemed by referring physician and/or radiation oncologist
- Pregnancy or breast feeding
The study team makes the final eligibility decision.
Where it's taking place
- Westmead, Australia
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Westmead, Australia. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.