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New treatment option for Functional Dyspepsia
Official title Synergistic Gut-brain Axis Modulation Via Vagal Stimulation and Support Therapy in Functional Dyspepsia
ClinicalTrials.gov ID: NCT06360900
What this study is testing
- What it's testing
- The study aims at evaluating physiological and patient-reported outcomes for a dual intervention approach including a stimulation device and support therapy in patients with functional dyspepsia.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 65
You may be able to join if
- Age 18-65 years old (inclusive)
- Ability to give written consent and participate in behavioral intervention in English
- Willingness to attend weekly treatment sessions over live video, daily self-administered transcutaneous auricular vagus nerve stimulation (taVNS)...
- Avoidance of alcohol, nicotine, and caffeine for 24 hours prior to study session
- Diagnosis according to the Rome IV criteria for both epigastric pain syndrome and postprandial distress syndrome subtypes
You likely can't join if
- Previous receipt of cognitive behavioral therapy (CBT) for gastrointestinal symptoms
- Enteral or parenteral feeding
- Previous gastrointestinal surgery, electrolyte disturbances, kidney dysfunction, renal insufficiency, or iron overload disorders
- Estimated Glomerular Filtration Rate (eGFR) \< 60
- Medications that affect gastrointestinal motility in addition to medications or products containing tetrahydrocannabinol (THC) will be stopped at...
- Intellectual disability by history
See the full eligibility criteria
- Age 18-65 years old (inclusive)
- Ability to give written consent and participate in behavioral intervention in English
- Willingness to attend weekly treatment sessions over live video, daily self-administered transcutaneous auricular vagus nerve stimulation (taVNS) sessions, and engage in homework during treatment
- Avoidance of alcohol, nicotine, and caffeine for 24 hours prior to study session
- Diagnosis according to the Rome IV criteria for both epigastric pain syndrome and postprandial distress syndrome subtypes
- Stable medical treatment for functional dyspepsia (FD) during 1 month before the study and during the study period
- Previous receipt of cognitive behavioral therapy (CBT) for gastrointestinal symptoms
- Enteral or parenteral feeding
- Previous gastrointestinal surgery, electrolyte disturbances, kidney dysfunction, renal insufficiency, or iron overload disorders
- Estimated Glomerular Filtration Rate (eGFR) \< 60
- Medications that affect gastrointestinal motility in addition to medications or products containing tetrahydrocannabinol (THC) will be stopped at least 7 days prior to the start of the study and for the duration of the...
- Intellectual disability by history
- Diabetes, mitochondrial disease, severe autonomic dysfunction, and small fiber polyneuropathy
- No active clinical acupuncture therapy
- Illicit drugs or opioid usage
- History of arrhythmias
- Current pregnancy/breastfeeding
- Contraindications for magnetic resonance imaging (MRI) (implanted ferromagnetic objects, claustrophobia)
- Weight \> 450 lbs. (limit of the MRI table)
- Allergy to pineapple (used in the test meal during MRI)
- Any other condition interfering with study requirements, according to the Investigator
The study team makes the final eligibility decision.
Where it's taking place
- Boston, Massachusetts, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 65 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Boston, Massachusetts, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.