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New treatment option for Opioid Use Disorder
Official title Adversity, Brain and Opioid Use Study
ClinicalTrials.gov ID: NCT06355778
What this study is testing
- What it's testing
- The way people process and remember information may be related to adverse childhood experiences and Opioid Use Disorder symptoms. The purpose of this project is to examine brain function and performance during learning and memory tasks in adults.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 55. Healthy volunteers may be eligible.
You may be able to join if
- for all groups:
- Fluent in English
- Able to give informed consent
- Normal/corrected-to-normal vision and hearing for Opioid Use Disorder (OUD) group:
- Diagnosis of OUD
You likely can't join if
- for all groups:
- Pregnancy
- Significant medical or neurologic conditions (e.g., stroke, seizures, multiple sclerosis)
- Actively suicidal
- Contraindication for MRI
- Inability to tolerate small, enclosed spaces without anxiety or unable to fit comfortably in the MRI scanner
See the full eligibility criteria
- for all groups:
- Fluent in English
- Able to give informed consent
- Normal/corrected-to-normal vision and hearing for Opioid Use Disorder (OUD) group:
- Diagnosis of OUD
- Be actively receiving buprenorphine (BUP) for opioid agonist therapy
- Be free from illicit substance use for at least 2 weeks
- The study will allow stable dose (\> 3 months) of commonly prescribed psychiatric medications and some sleep aids (per protocol) for the BUP control group:
- Taking BUP for chronic pain
- No Substance Use Disorder (including OUD)
- The study will allow stable dose (\> 3 months) of commonly prescribed psychiatric medications and some sleep aids (per protocol) for Healthy participant group:
- Not taking BUP
- Free of any psychiatric or major medical conditions
- for all groups:
- Pregnancy
- Significant medical or neurologic conditions (e.g., stroke, seizures, multiple sclerosis)
- Actively suicidal
- Contraindication for MRI
- Inability to tolerate small, enclosed spaces without anxiety or unable to fit comfortably in the MRI scanner
- Life history of schizophrenia, learning disability, attention deficit disorder, or pervasive developmental disorder
- Use of substances or prescription medications that could interfere with measures of interest (per protocol)
- Unable to provide informed consent
- Participants who have completed other studies in our lab involving learning and memory assessments with the same/similar tasks used here (HUM00230585, HUM00121812) will not be eligible to complete the current study, due...
The study team makes the final eligibility decision.
Where it's taking place
- Ann Arbor, Michigan, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 55 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Ann Arbor, Michigan, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.