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New treatment option for Cancer
Official title Transarterial Chemoembolization (TACE) Plus Bevacizumab for Liver Metastases
ClinicalTrials.gov ID: NCT06311851
What this study is testing
What is Bevacizumab?
Bevacizumab is an investigational medicine, given as an infusion into a vein, being studied as a potential treatment for cancer.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- Trans arterial chemoembolization (TACE) has emerged as a treatment option for chemotherapy-refractory diseases in Liver metastases. By delivering chemotherapy agents directly to the tumor site, TACE can maximize local drug concentrations and reduce systemic adverse reactions.
- Phase 2: a mid-size study of how well it works
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 80
You may be able to join if
- Confirmation of metastatic liver cancer via histological examination or a characteristic imaging profile on dynamic computed tomography (CT) scan or...
- Eastern cooperative oncology group performance status (ECOGPS) of 0 or 1
- Liver function categorized as Child-Pugh class A or B
- Stable non-hepatic metastases, such as skeletal, pulmonary, or lymph node metastases
- Hepatic tumor burden below 70%
You likely can't join if
- Active infection
- Presence of severe comorbidities, such as hepatic encephalopathy, refractory ascites, and esophageal variceal bleeding
- Prior liver resection
- Previous TACE therapy received at other healthcare facilities
- Poor performance status (ECOGPS \> 1)
See the full eligibility criteria
- Confirmation of metastatic liver cancer via histological examination or a characteristic imaging profile on dynamic computed tomography (CT) scan or magnetic resonance imaging (MRI) without indications for surgical...
- Eastern cooperative oncology group performance status (ECOGPS) of 0 or 1
- Liver function categorized as Child-Pugh class A or B
- Stable non-hepatic metastases, such as skeletal, pulmonary, or lymph node metastases
- Hepatic tumor burden below 70%
- Expected survival duration exceeding six months
- Laboratory findings meeting specific criteria, including platelet count \>50×109 /L, hemoglobin \>8.0 g/dL, ANC count ≥1.5 × 109/L, bilirubin \<51 mmol/L, alanine and aspartate aminotransferase \<3 times the upper limit...
- Active infection
- Presence of severe comorbidities, such as hepatic encephalopathy, refractory ascites, and esophageal variceal bleeding
- Prior liver resection
- Previous TACE therapy received at other healthcare facilities
- Poor performance status (ECOGPS \> 1)
The study team makes the final eligibility decision.
Where it's taking place
- Tehran, Tehran Province, Iran
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 80 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Tehran, Tehran Province, Iran. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.