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New treatment option for Obesity
Official title Experimental Approach to Test Predictions of Body Weight Regulation Models
ClinicalTrials.gov ID: NCT06309576
What this study is testing
- What it's testing
- The regulation of human body weight and fatness is not fully understood. Although some models of regulation have been proposed (set point, dual-intervention point, others), no studies have been designed to test their predictions.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 40. Healthy volunteers may be eligible.
You may be able to join if
- Body mass index lower than 20 kg/m2 for the low body weight group, or 30 kg/m2 or greater for the obesity group
- 18-40 years old
- Nulliparous and regular menstrual cycle (25-35 days) during the last six months (in women)
- Normal thyroid function, blood count, and chemistry 15 panel (normal plasma glucose will be considered at \ =50 mg/dL for women and \>=40 mg/dL for...
- Self-reported weight stability during the last six months (±3 kg)
You likely can't join if
- Eating disorders as indicated by a global score ≥2.80 in the Eating Disorder Examination Questionnaire, or a previous diagnosis of an eating disorder
- For the low body weight group, having food insecurity (with or without hunger) as assessed by the USDA
- Recreational moderate-intensity physical activity ≥150 min/week, recreational vigorous-intensity physical activity ≥75 min/week, or a combination of...
- Cigarette or vape smoking
- Intake of more than 14 alcoholic drinks per week
- Use of medications that may affect energy intake and/or expenditure, for example, semaglutide, liraglutide, exenatide, other GLP-1 receptor agonists...
See the full eligibility criteria
- Body mass index lower than 20 kg/m2 for the low body weight group, or 30 kg/m2 or greater for the obesity group
- 18-40 years old
- Nulliparous and regular menstrual cycle (25-35 days) during the last six months (in women)
- Normal thyroid function, blood count, and chemistry 15 panel (normal plasma glucose will be considered at \ =50 mg/dL for women and \>=40 mg/dL for men; and normal serum triglycerides at \<150 mg/dL).
- Self-reported weight stability during the last six months (±3 kg)
- Rate the liking of at least one of the flavored liquid meals (Ensure Plus, Abbot Nutrition) between 5 and 8 on a 9-point Likert scale
- Willing to only drink up to two assigned flavors of Ensure Plus for two consecutive days
- Eating disorders as indicated by a global score ≥2.80 in the Eating Disorder Examination Questionnaire, or a previous diagnosis of an eating disorder
- For the low body weight group, having food insecurity (with or without hunger) as assessed by the USDA
- Recreational moderate-intensity physical activity ≥150 min/week, recreational vigorous-intensity physical activity ≥75 min/week, or a combination of recreational moderate-intensity and vigorous-intensity physical...
- Cigarette or vape smoking
- Intake of more than 14 alcoholic drinks per week
- Use of medications that may affect energy intake and/or expenditure, for example, semaglutide, liraglutide, exenatide, other GLP-1 receptor agonists, phentermine-topiramate, naltrexone-bupropion, orlistat, metformin...
- Human immunodeficiency virus, galactosemia, and lactose intolerance
- Diseases that affect energy homeostasis including endocrine such as hypo/hyperthyroidism, or type 1 or 2 diabetes; cancer; chronic pulmonary diseases; cardiovascular disease; and renal disease
- History of inflammatory bowel disease (ulcerative colitis, Crohn's), malabsorption syndromes (intestinal, pancreatic), and sprue or gluten intolerance
- Having moderate to severe sleep apnea defined as an oxygen desaturation index \>10 times/hour assessed by overnight oximetry to be conducted on the night following the screening visit
- Use of oral hormonal contraceptives or less than 6 months using a hormonal intrauterine device (in women)
- Adults who are unable to consent
- Prisoners
- Currently pregnant or breastfeeding (in women)
The study team makes the final eligibility decision.
Where it's taking place
- Baton Rouge, Louisiana, United States
Compensation & support
Compensation mentioned.
ClinicalTrials.gov doesn't provide a reliable structured field for payment or travel support - confirm details with the study team.
Questions & answers
Do participants get paid in this trial?
This study's listing includes signals that participants may be compensated or receive a stipend. Amounts vary and are set by the study team - confirm the details with them.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 40 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Baton Rouge, Louisiana, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.