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New treatment option for Postoperative Pulmonary Complications
Official title The Effect of Continuous Intravenous Infusion of Lidocaine on PPCs and Prognosis in Emergency Surgical Patients With IAI
ClinicalTrials.gov ID: NCT06304779
What this study is testing
What is Lidocaine?
Lidocaine is an investigational medicine, given as an infusion into a vein, being studied as a potential treatment for postoperative pulmonary complications.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- The main purpose of this study is to evaluate the impact of continuous 24-hour intravenous infusion of lidocaine on the incidence of PPCs in patients undergoing emergency laparotomy for intra-abdominal infection (IAI).The secondary objectives of this study are to assess the impact of continuous 24-hour intravenous lidocaine infusion on the proportion of patients requiring mechanical ventilation, protection of important organ function during the perioperative period, length of hospital stay, and outcomes within 30 days postoperatively.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 100
You may be able to join if
- Age \>18 years, any gender.
- Patients suspected of digestive tract perforation or obstruction based on physical examination, confirmed by imaging, requiring emergency surgical...
- The anesthesia method is general anesthesia
- I or the patient's family have carefully read and signed the informed consent form
- Serum procalcitonin (PCT) at inflammatory levels or leukocytosis (\>12×109/L) or leukopenia (\ 10% naive leukocytes
You likely can't join if
- Have a history of local anesthesia drug allergy
- Pregnant patients
- Patients receiving renal replacement therapy
- Patients with arrhythmias or heart failure (second or third-degree atrioventricular block or left ventricular ejection fraction（LVEF）
- Preoperative platelet count\<80 × 109/L
- Patients who require secondary surgery for postoperative anastomotic fistula
See the full eligibility criteria
- Age \>18 years, any gender.
- Patients suspected of digestive tract perforation or obstruction based on physical examination, confirmed by imaging, requiring emergency surgical treatment.
- The anesthesia method is general anesthesia
- I or the patient's family have carefully read and signed the informed consent form
- Serum procalcitonin (PCT) at inflammatory levels or leukocytosis (\>12×109/L) or leukopenia (\ 10% naive leukocytes
- Have a history of local anesthesia drug allergy
- Pregnant patients
- Patients receiving renal replacement therapy
- Patients with arrhythmias or heart failure (second or third-degree atrioventricular block or left ventricular ejection fraction（LVEF）
- Preoperative platelet count\<80 × 109/L
- Patients who require secondary surgery for postoperative anastomotic fistula
- Patients who have participated in other clinical studies
The study team makes the final eligibility decision.
Where it's taking place
- Shanghai, Shanghai Municipality, China
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 100 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Shanghai, Shanghai Municipality, China. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.