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New treatment option for Solid Tumor
Official title Study of STP938 (Dencatistat) in Advanced Solid Tumours
ClinicalTrials.gov ID: NCT06297525
What this study is testing
What is STP938?
STP938 is an investigational medicine, being studied as a potential treatment for solid tumor.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- The Phase 1a part of the study is a dose escalation of STP938 as a monotherapy. The Phase 1b part of the study is a safety expansion cohort of STP938 as a monotherapy.
- Phase 1: an early, usually small safety study
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Main
- Signed and dated informed consent, and able to comply with the study procedures and any locally required authorization.
- Male or female aged ≥ 18 years.
- Advanced disease not curable by available therapies and requires systemic therapy.
- Histologically confirmed diagnosis of eligible cancer type.
You likely can't join if
- Pregnant or breastfeeding females and women of childbearing potential or males unwilling to comply with contraception requirements.
- Known active or symptomatic CNS metastases, carcinomatous meningitis, leptomeningeal disease or a history of spinal cord compression
- Active malignancy within 2 years of study enrollment
- Prior radiation within 2 weeks of start of therapy.
- Systemic cancer treatments, monoclonal antibody-directed therapies, other investigational agents within 4 weeks before enrollment, or \<5 half-lives...
- Uncontrolled intercurrent illness.
See the full eligibility criteria
- Main
- Signed and dated informed consent, and able to comply with the study procedures and any locally required authorization.
- Male or female aged ≥ 18 years.
- Advanced disease not curable by available therapies and requires systemic therapy.
- Histologically confirmed diagnosis of eligible cancer type.
- Must have tumor tissue available for biomarker testing.
- Measurable disease (Part 1) and measurable disease per RECIST (Part2)
- Eastern Cooperative Oncology Group (ECOG) performance status ≤2.
- Life expectancy \> 3 months as assessed by the Investigator.
- Adequate organ function (bone marrow, hepatic, renal function and coagulation).
- All toxicities (except alopecia) from prior cancer treatments or procedures must have resolved to ≤Grade 1 or returned to baseline levels prior to enrollment. Main
- Pregnant or breastfeeding females and women of childbearing potential or males unwilling to comply with contraception requirements.
- Known active or symptomatic CNS metastases, carcinomatous meningitis, leptomeningeal disease or a history of spinal cord compression
- Active malignancy within 2 years of study enrollment
- Prior radiation within 2 weeks of start of therapy.
- Systemic cancer treatments, monoclonal antibody-directed therapies, other investigational agents within 4 weeks before enrollment, or \<5 half-lives since completion of previous investigational therapy, whichever is...
- Uncontrolled intercurrent illness.
- Immunocompromised people with increased risk of opportunistic infections or history of opportunistic infection in the last 12 months.
- Known active or chronic hepatitis B or active hepatitis C virus (HCV) infection.
- people with corrected QT interval \>470 msec based on averaged triplicate electrocardiogram (ECG) readings at the Screening Visit using the QT interval corrected for heart rate using Fridericia's method (QTcF).
The study team makes the final eligibility decision.
Where it's taking place
- St. Petersburg, Florida, United States
- Dallas, Texas, United States
- San Antonio, Texas, United States
- Villejuif, Paris, France
- Glasgow, Glasgow, United Kingdom
- London, United Kingdom
- Manchester, United Kingdom
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include St. Petersburg, Florida, United States; Dallas, Texas, United States; San Antonio, Texas, United States; Villejuif, Paris, France; Glasgow, Glasgow, United Kingdom; London, United Kingdom and 1 more location(s). Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.