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New treatment option for Adolescence
Official title Exercise Facilitation of Adolescent Fear Extinction, Frontolimbic Circuitry, and Endocannabinoids
ClinicalTrials.gov ID: NCT06297278
What this study is testing
- What it's testing
- Anxiety disorders commonly begin during adolescence, and are characterized by deficits in the ability to inhibit or extinguish pathological fear. Recent research has provided new understanding of how fear is learned and can be regulated in the adolescent brain, and how the endocannabinoid system shapes these processes; however, these advances have not yet translated into improved therapeutic outcomes for adolescents with anxiety.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 14 to 17. Healthy volunteers may be eligible.
You may be able to join if
- Provision of signed and dated informed consent form
- Stated willingness to comply with all study procedures and available for the duration of the study
- 14-17 years of age upon enrollment
- Right-handed
- In good general health as evidenced by medical history
You likely can't join if
- Traumatic brain injury with ongoing symptoms
- Sensory (e.g., hearing) or physical (e.g., motor, balance) impairment or significant developmental delay
- MRI participants: MRI contraindication (e.g., braces, implants, claustrophobia)
- Any condition that would contraindicate blood draws (e.g., hemophilia, sickle cell)
- Past or current diagnosis or presence of likely neurological disorder (e.g., epilepsy), psychotic disorder (e.g., schizophrenia, schizoaffective...
- Severe/unstable medical condition (e.g., diabetes, rheumatoid arthritis)
See the full eligibility criteria
- Provision of signed and dated informed consent form
- Stated willingness to comply with all study procedures and available for the duration of the study
- 14-17 years of age upon enrollment
- Right-handed
- In good general health as evidenced by medical history
- Adolescent and parent/guardian are English-speaking, as study assessments are in English
- Availability of a parent or legal guardian who is willing to provide consent and attend all study visits
- Traumatic brain injury with ongoing symptoms
- Sensory (e.g., hearing) or physical (e.g., motor, balance) impairment or significant developmental delay
- MRI participants: MRI contraindication (e.g., braces, implants, claustrophobia)
- Any condition that would contraindicate blood draws (e.g., hemophilia, sickle cell)
- Past or current diagnosis or presence of likely neurological disorder (e.g., epilepsy), psychotic disorder (e.g., schizophrenia, schizoaffective disorder), or bipolar disorder
- Severe/unstable medical condition (e.g., diabetes, rheumatoid arthritis)
- Current (past 1-month) use of cannabis or cannabinoid products including CBD unless willing to stop for at least 4 weeks prior to entering the study
- Currently pregnant, lactating, or positive pregnancy test at screening visit
- Current homicidal thoughts or suicide attempt in the past year
- Current suicidal thoughts requiring immediate intervention
- Concurrent use (past 6 weeks) of oral contraceptives
- Diagnosed or probable substance use disorder (past 1-month)
- Positive drug test at baseline visit (e.g., THC, cocaine)
- Moderate/severe drug or alcohol use in the past 8 weeks
- Current or recent (past 1-month) COVID-19 diagnosis or febrile illness
- Treatment with investigational drug or intervention (past 1-month)
- Current smoker, vaper, or tobacco or nicotine use (past 1-month)
- Ongoing exposure to abuse
The study team makes the final eligibility decision.
Where it's taking place
- Detroit, Michigan, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 14 years to 17 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Detroit, Michigan, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.