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New treatment option for Hypophysectomy
Official title Hypophysectomy by Stereotactic Radiosurgery for Cancer-Related Pain
ClinicalTrials.gov ID: NCT06287515
What this study is testing
- What it's testing
- To learn if hypophysectomy (treatment of the pituitary gland) using a type of radiation treatment called stereotactic radiosurgery (SRS) can help to relieve cancer-related pain.
- Phase 1: an early, usually small safety study
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Age ≥ 18 years old on the day of signing informed consent and willing and able to sign a written informed consent.
- English fluency in order to complete PROs and neurocognitive assessment
- Pathologic or cytologic confirmation of malignancy.
- Poorly controlled intractable nociceptive or mixed pain limiting function or quality of life. Participants must have exhausted or not a candidate for...
- ECOG performance status of 0-3.
You likely can't join if
- Participants with prior cranial or head/neck radiation where cumulative organ-at-risk dose constraints cannot be achieved (see section 4.2).
- Inability to have an MRI of the brain for reasons such as a non-compatible bioimplant that could be displaced during MRI, shrapnel embedded (such as...
- Expressions of pain due to depression, delirium or addictive behavior
- Participants who are pregnant.
- Known psychiatric or substance abuse disorders that would interfere with cooperation with the requirements of the study in the judgment of the...
See the full eligibility criteria
- Age ≥ 18 years old on the day of signing informed consent and willing and able to sign a written informed consent.
- English fluency in order to complete PROs and neurocognitive assessment
- Pathologic or cytologic confirmation of malignancy.
- Poorly controlled intractable nociceptive or mixed pain limiting function or quality of life. Participants must have exhausted or not a candidate for standard of care pain control measures such as opioids...
- ECOG performance status of 0-3.
- Life expectancy is greater than 4 weeks and less than 1 year in the treating physician's judgment.
- Participants with prior cranial or head/neck radiation where cumulative organ-at-risk dose constraints cannot be achieved (see section 4.2).
- Inability to have an MRI of the brain for reasons such as a non-compatible bioimplant that could be displaced during MRI, shrapnel embedded (such as from war wounds), metal workers, and machinists (potential for...
- Expressions of pain due to depression, delirium or addictive behavior
- Participants who are pregnant.
- Known psychiatric or substance abuse disorders that would interfere with cooperation with the requirements of the study in the judgment of the Investigators.
The study team makes the final eligibility decision.
Where it's taking place
- Houston, Texas, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Houston, Texas, United States. Enter your location above to see the nearest site and check your eligibility.
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BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.