BridgeMD
New treatment option for Postpartum Hemorrhage
Official title Effect of Ephedrine, Phenylepinephrine, and Norepinephrine on Myometrial Contractility in Pregnant People With Type II and Gestational Diabetes During Cesarean Section: An In-vitro Study
ClinicalTrials.gov ID: NCT06285396
What this study is testing
What is Ephedrine?
Ephedrine is an investigational medicine, being studied as a potential treatment for postpartum hemorrhage.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- The goal of this study is to learn about how medication that is used to help treat low blood pressure during a Cesarean delivery (CD) can cause changes to the uterine muscle tissue and its ability to contract, in patients with Type II and gestational diabetes. Spinal anesthesia administered during elective CD has been known to cause hypotension (low blood pressure) as a side effect during the procedure, and is prevented by administration of vasopressors (medication to raise blood pressure) by the anesthesiologist after the delivery of the baby.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 19 to 45, women only. Healthy volunteers may be eligible.
You may be able to join if
- Patients who have given consent to participate in the study
- Patients with gestational age 37-41 weeks
- Patients previously diagnosed with either Type II or Gestational diabetes. For the healthy control group, no previous diagnosis is required for...
- Patients of 19-45 years
- Patients of normal BMI (18-30 BMI) for the healthy control group only
You likely can't join if
- Patients who refuse to give written informed consent
- Patients who require general anesthesia
- Patients in labor and those receiving oxytocin for induction of labor
- Emergency caesarean delivery in labor
- Patients who have had previous uterine surgery involving myometrial dissection or \>1 previous caesarean delivery
- Patients with risk factors for PPH such as those with polyhydramnios, preeclampsia, multiple gestation, morbid obesity, macrosomia (large for size...
See the full eligibility criteria
- Patients who have given consent to participate in the study
- Patients with gestational age 37-41 weeks
- Patients previously diagnosed with either Type II or Gestational diabetes. For the healthy control group, no previous diagnosis is required for inclusion
- Patients of 19-45 years
- Patients of normal BMI (18-30 BMI) for the healthy control group only
- Baby is registered as normal weight for size for the healthy control group only
- Non-laboring patients, not exposed to exogenous oxytocin
- Patients requiring elective primary or first repeat caesarean delivery
- Patients undergoing caesarean delivery under spinal anesthesia
- Patients who refuse to give written informed consent
- Patients who require general anesthesia
- Patients in labor and those receiving oxytocin for induction of labor
- Emergency caesarean delivery in labor
- Patients who have had previous uterine surgery involving myometrial dissection or \>1 previous caesarean delivery
- Patients with risk factors for PPH such as those with polyhydramnios, preeclampsia, multiple gestation, morbid obesity, macrosomia (large for size baby), and previous history of PPH. However, for diabetic group, those...
- For the healthy control group only, a BMI \>30 or \<18
- Maternal age \>45
The study team makes the final eligibility decision.
Where it's taking place
- Toronto, Ontario, Canada
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling female, 19 years to 45 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Toronto, Ontario, Canada. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.