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New treatment option for Dental Implant
Official title Influence of Timing of Implant Placement on Early Healing Molecular Events
ClinicalTrials.gov ID: NCT06276335
What this study is testing
- What it's testing
- Dental implants have been on the market for several years and they are routinely used to replace single/multiple missing teeth with a high success rate. However, there is still a limited number of studies comparing the influence of timing of implant placement on wound healing.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 25 and older
You may be able to join if
- Age ≥25 years old
- Good/controlled medical and psychological health
- Good oral hygiene (FMPS≤20%)
- Presence of a tooth in the aesthetic region (from incisor to second premolar) in need of extraction and further oral rehabilitation with a single...
- For the IP group, the extraction socket should fulfil the following parameters, as described by the 5th ITI consensus [46]: intact socket wall...
You likely can't join if
- Any known systemic disease severely affecting bone metabolism (e.g., Cushing's syndrome, Crohn's disease, rheumatoid arthritis, osteoporosis or...
- Self-reported HIV or viral hepatitis.
- Self-reported alcoholism or chronic drug abuse.
- Smokers (including current smokers or former smokers who had quit for \< 3 months); patients reporting use of vape/e-cigarettes will also be excluded.
- Self-reported pregnancy or lactation (this criterion is due to oral tissue changes related to pregnancy and nursing, which can affect interpretation...
- Chronic treatment (i.e., 2 weeks or more) with any medication known to affect oral status or bone metabolism (e.g., bisphosphonates, hormone...
See the full eligibility criteria
- Age ≥25 years old
- Good/controlled medical and psychological health
- Good oral hygiene (FMPS≤20%)
- Presence of a tooth in the aesthetic region (from incisor to second premolar) in need of extraction and further oral rehabilitation with a single dental implant.
- For the IP group, the extraction socket should fulfil the following parameters, as described by the 5th ITI consensus [46]: intact socket wall; facial bone wall ≥1mm in thickness; no acute infection at the site...
- At least one neighbouring natural tooth.
- A functional occlusion with a minimum of four occlusal units (i.e., pairs of occluding posterior teeth).
- Willingness to read and sign a copy of the Informed Consent Form (ICF) after reading the Patient Information Sheet (PIS), and after the nature of the study has been fully explained and potential questions fully answered.
- Any known systemic disease severely affecting bone metabolism (e.g., Cushing's syndrome, Crohn's disease, rheumatoid arthritis, osteoporosis or diabetes type I and uncontrolled diabetes type II).
- Self-reported HIV or viral hepatitis.
- Self-reported alcoholism or chronic drug abuse.
- Smokers (including current smokers or former smokers who had quit for \< 3 months); patients reporting use of vape/e-cigarettes will also be excluded.
- Self-reported pregnancy or lactation (this criterion is due to oral tissue changes related to pregnancy and nursing, which can affect interpretation of study results).
- Chronic treatment (i.e., 2 weeks or more) with any medication known to affect oral status or bone metabolism (e.g., bisphosphonates, hormone replacement therapy, immunosuppressants) within 1 month before baseline visit.
- Chronic treatment with anticoagulants (including Aspirin), corticosteroids, immunosuppressants or other medications that may influence blood coagulation/count.
- Antibiotic or anti-inflammatory therapy during the month preceding the baseline exam.
- Untreated caries lesions and untreated/uncontrolled periodontal disease; If patients require periodontal treatment (non-surgical and/or surgical), this will be arranged outside the study protocol and completed prior to...
- Inadequate keratinized tissue width (\<2 mm) in the mid-buccal aspect of the area to be treated in the study.
- Physical handicaps that would interfere with the ability to perform adequate oral hygiene in the area of implant placement.
- Patients requiring maxillary sinus lift surgery before implant placement.
- Self-reported bruxism.
- Patients not willing to receive animal-derived biomaterials for GBR.
- Patients suffering from a known psychological disorder or with limited mental capacity or language skills such that study information could not be understood, informed consent could not be obtained, or simple...
- Other severe acute or chronic medical or psychiatric condition or laboratory abnormality that may increase the risk associated with trial participation or may interfere with the interpretation of trial results and, in...
The study team makes the final eligibility decision.
Where it's taking place
- London, United Kingdom
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 25 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include London, United Kingdom. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.