BridgeMD
New treatment option for Rheumatic Fever
Official title TREAT-SC: Early, Short Course Oral Dexamethasone for the Treatment of Sydenham Chorea in Children
ClinicalTrials.gov ID: NCT06259006
What this study is testing
What is Dexamethasone Oral?
Dexamethasone Oral is an investigational medicine, given as an injection under the skin, being studied as a potential treatment for rheumatic fever.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- The purpose of this study is to find out whether an early three-day course of an oral steroid medication (dexamethasone) can improve the physical and mental recovery and wellbeing for children with Sydenham's chorea. Sydenham's chorea is a condition that impacts approximately 12% of children with acute rheumatic fever.
- Phase 3: a large, late-stage study
- You might receive a placebo (an inactive treatment) instead of the study drug, decided by chance. You may not know which one you got.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 4 to 17
You may be able to join if
- Sydenham's chorea of any severity diagnosed by a paediatrician or neurologist based on national ARF guidelines
- Child or adolescents aged 4 years to \<18 years of age
You likely can't join if
- Administered steroids or intravenous immunoglobulin since onset of the current Sydenham's chorea episode
- Evidence of concomitant severe, acute infection
- History of hypersensitivity to dexamethasone or its excipients
- Pregnancy
- Confirmed exposure of an unimmunised child to measles, mumps, rubella or chickenpox within the previous four weeks
- Receipt of a live vaccine within the previous four weeks
See the full eligibility criteria
- Sydenham's chorea of any severity diagnosed by a paediatrician or neurologist based on national ARF guidelines
- Child or adolescents aged 4 years to \<18 years of age
- Administered steroids or intravenous immunoglobulin since onset of the current Sydenham's chorea episode
- Evidence of concomitant severe, acute infection
- History of hypersensitivity to dexamethasone or its excipients
- Pregnancy
- Confirmed exposure of an unimmunised child to measles, mumps, rubella or chickenpox within the previous four weeks
- Receipt of a live vaccine within the previous four weeks
- Medical condition or treatment with medication which in the opinion of the trial investigators would make the child unsuitable for the trial
The study team makes the final eligibility decision.
Where it's taking place
- Darwin, Northern Territories, Australia
- Auckland, New Zealand
- Gisborne, New Zealand
- Hamilton, New Zealand
- Hastings, New Zealand
- Lower Hutt, New Zealand
- Masterton, New Zealand
- New Plymouth, New Zealand
- Palmerston North, New Zealand
- Rotorua, New Zealand
- Tauranga, New Zealand
- Wellington, New Zealand
- Whakatāne, New Zealand
- Whanganui, New Zealand
- Whangarei, New Zealand
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 4 years to 17 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Darwin, Northern Territories, Australia; Auckland, New Zealand; Gisborne, New Zealand; Hamilton, New Zealand; Hastings, New Zealand; Lower Hutt, New Zealand and 9 more location(s). Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.