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New treatment option for Acute Kidney Injury
Official title Fluid-removal Guided by VeXUS Score With Usual Care in Patients With Acute Kidney Injury After Cardiac Surgery
ClinicalTrials.gov ID: NCT06251713
What this study is testing
- What it's testing
- Acute kidney injury affects more than 30% of patients after cardiac surgery, and is associated with an excess in mortality. There is a clinical continuum between acute kidney injury (transient if \ 48h), the development of acute kidney and chronic renal failure.
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 85
You may be able to join if
- Intensive care unit admission within 72 hours of cardiac surgery with extracorporeal circulation
- Acute kidney injury defined by KDIGO criteria
- Vasoactive inotropic score \<45 and capillary refill time \<3s
- Informed written consent
You likely can't join if
- Hypokalaemia \<3.5mmol/L
- Hyponatremia\<125mmol/L
- Hypernatremia \>145mmol/L
- Metabolic alkalosis with pH \>7.50
- Impossibility to measure capillary refill time
- Chronic liver disease
See the full eligibility criteria
- Intensive care unit admission within 72 hours of cardiac surgery with extracorporeal circulation
- Acute kidney injury defined by KDIGO criteria
- Vasoactive inotropic score \<45 and capillary refill time \<3s
- Informed written consent
- Hypokalaemia \<3.5mmol/L
- Hyponatremia\<125mmol/L
- Hypernatremia \>145mmol/L
- Metabolic alkalosis with pH \>7.50
- Impossibility to measure capillary refill time
- Chronic liver disease
- Cirrhosis with portal hypertension
- Known thrombus of the inferior vena cava
- Mechanical circulatory assistance (ECMO or mono left ventricular assistance)
- Severe pre-operative chronic kidney disease (GFR \< 30mL/min/1.73m2)
- Need for renal replacement therapy anticipated by the attending physician within 24 hours
- Known hypersensitivity to Furosemide and/or hydrochlorothiazide
- Severe allergy to wheat
- Patient already included in another treatment study with an exclusion period still in progress
- Pregnant, breast-feeding or women of childbearing age without suitable contraception
- Patients under guardianship, curatorship or safeguard of justice
- Patients under psychiatric care
- Patients not affiliated to a social security scheme or beneficiaries of a similar scheme
The study team makes the final eligibility decision.
Where it's taking place
- Bron, Bron, France
- Bron, France
Compensation & support
Compensation mentioned.
ClinicalTrials.gov doesn't provide a reliable structured field for payment or travel support - confirm details with the study team.
Questions & answers
Do participants get paid in this trial?
This study's listing includes signals that participants may be compensated or receive a stipend. Amounts vary and are set by the study team - confirm the details with them.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 85 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Bron, Bron, France; Bron, France. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.