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New treatment option for Hypertension, Resistant to Conventional Therapy
Official title Antihypertensive Mechanisms of Minocycline in Resistant Hypertension
ClinicalTrials.gov ID: NCT06246396
What this study is testing
What is Minocycline Hydrochloride?
Minocycline Hydrochloride is an investigational medicine, given as an once-daily, being studied as a potential treatment for hypertension, resistant to conventional therapy.
Also referred to as Minocycline, Minocin.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- The goal of this clinical trial is to learn about the mechanisms by which minocycline effect blood pressure in individuals with treatment-resistant hypertension. The main questions it aims to answer are: To what extent does minocycline lower blood pressure?
- Phase 4: studies an already-approved treatment
- Time commitment: about 3 months
- You might receive a placebo (an inactive treatment) instead of the study drug. You may not know which one you got.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 100
You may be able to join if
- Age ≥18 years
- Uncontrolled TRH, defined as uncontrolled blood pressure (mean 24-hour ambulatory systolic BP ≥125 mm Hg or diastolic BP ≥80 mm Hg) while being...
- The participant agrees to have all study procedures performed
You likely can't join if
- Known hypersensitivity or contraindication to minocycline or other tetracyclines
- Recent (≤3 months prior), ongoing, or expected use of oral antibiotics
- Estimated glomerular filtration rate (eGFR) of \<45mL/min/1.73m2, using the MDRD equation
- Known secondary hypertension
- History of hypertensive crisis, defined as any in-patient hospitalizations for hypertensive crisis/emergency within the past year
- History of orthostatic hypotension, defined as two or more episode(s) of orthostatic hypotension (reduction of SBP of \>20 mm Hg or DBP of \>10 mm Hg...
See the full eligibility criteria
- Age ≥18 years
- Uncontrolled TRH, defined as uncontrolled blood pressure (mean 24-hour ambulatory systolic BP ≥125 mm Hg or diastolic BP ≥80 mm Hg) while being adherent to a stable (no changes in ≥14 days prior) antihypertensive...
- The participant agrees to have all study procedures performed
- Known hypersensitivity or contraindication to minocycline or other tetracyclines
- Recent (≤3 months prior), ongoing, or expected use of oral antibiotics
- Estimated glomerular filtration rate (eGFR) of \<45mL/min/1.73m2, using the MDRD equation
- Known secondary hypertension
- History of hypertensive crisis, defined as any in-patient hospitalizations for hypertensive crisis/emergency within the past year
- History of orthostatic hypotension, defined as two or more episode(s) of orthostatic hypotension (reduction of SBP of \>20 mm Hg or DBP of \>10 mm Hg within 3 minutes of standing) in the past year
- History of myocardial infarction, unstable angina, syncope, or cerebrovascular accident in prior 6 months
- Evidence of alcoholism or drug abuse
- Severe comorbid conditions (i.e., neoplasms or HIV positive or AIDS)
- Current pregnancy or anticipated pregnancy during the study.
The study team makes the final eligibility decision.
Where it's taking place
- Gainesville, Florida, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The study runs about 3 months per participant, based on its public description. The team confirms the exact schedule and number of visits before you enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 100 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Gainesville, Florida, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.