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New treatment option for Ischemic Stroke
Official title Combined taVNS and tDCS in Subacute Stroke Patients
ClinicalTrials.gov ID: NCT06244914
What this study is testing
- What it's testing
- Ischemic stroke, the most prevalent neurological disorder, is treated with medication and thrombectomy but with limited success, especially in chronic stages where traditional rehabilitation is the primary option. Stroke often leads to post-stroke autonomic imbalance, deteriorating functional outcomes and increasing recurrence risk.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Age ≥ 18 years old
- Subacute ischemic stroke patients within 7-30 days after stroke symptoms is stabilized
- Stroke will be documented by DWI-MRI
- Lesion locations at least involve supratentorial area
- Patients have unilateral weakness documented with manual muscle testing scales less than 4
You likely can't join if
- A National Institute of Health Stroke Scale (NIHSS) score \> 25 at study entry
- The presence of hemineglect
- Moderate-to-severe pain in any limb
- Unstable clinical condition
- Recurrent strokes or brainstem strokes
- Marked arrhythmia or cardiovascular complications
See the full eligibility criteria
- Age ≥ 18 years old
- Subacute ischemic stroke patients within 7-30 days after stroke symptoms is stabilized
- Stroke will be documented by DWI-MRI
- Lesion locations at least involve supratentorial area
- Patients have unilateral weakness documented with manual muscle testing scales less than 4
- Stable vital signs and stable neurological signs
- Able to receive regular rehabilitation programs, and 8) modified Rankin Scales (mRS) less than 5.
- A National Institute of Health Stroke Scale (NIHSS) score \> 25 at study entry
- The presence of hemineglect
- Moderate-to-severe pain in any limb
- Unstable clinical condition
- Recurrent strokes or brainstem strokes
- Marked arrhythmia or cardiovascular complications
- Bradycardia (HR≤50 bpm) or low blood pressure (SBP≤100 mmHg or DBP≤60mmHg) at admission
- Patients with radiographic evidence or suspicion of chronic conditions that may predispose them to intracranial hemorrhage including brain arteriovenous malformations, cerebral cavernous malformations, cerebral...
- Pre-existing coagulopathy, consist of platelet count of ≤100, INR≥ 3, PTT≥ 90
- Patients suspected of having infective endocarditis and ischemic stroke related to septic emboli
- Signs or symptoms of acute myocardial infarction, including EKG findings
- Concomitant experimental therapy
- Suspected cerebral vasculitis based on medical history and CTA/Magnetic Resonance Angiogram (MRA)
- Suspected cranial dural arteriovenous fistula, and evidence of dissection in the intracranial cerebral arteries
- Cerebral venous thrombosis and significant mass effect with midline shift
- History of left atrial myxoma
- Presence of contraindication for VNS (TENS) and tDCS: (A) Intracranial space occupied lesion, (B) Presence of a pacemaker, (C) History of brain neurosurgery, (D) Active CNS or systemic infection, (E) Presence of a...
- Not suitable for equipping ECG recorders: (A) Chronic disease, and allergic to polyester, (B) Acute and severe patients
The study team makes the final eligibility decision.
Where it's taking place
- Tainan, Tainan, Taiwan
Compensation & support
Compensation mentioned.
ClinicalTrials.gov doesn't provide a reliable structured field for payment or travel support - confirm details with the study team.
Questions & answers
Do participants get paid in this trial?
This study's listing includes signals that participants may be compensated or receive a stipend. Amounts vary and are set by the study team - confirm the details with them.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Tainan, Tainan, Taiwan. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.