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New treatment option for Aging
Official title Breaking Sitting with High-intensity Interval Training for Brain Health
ClinicalTrials.gov ID: NCT06243016
What this study is testing
- What it's testing
- This trial will examine whether interrupting 3.5 hours of sitting every 30 min with 6 min high intensity interval training (HIIT) breaks compared to light intensity interval training (LIIT) will improve brain health in cognitively normal older adults. This trial will test the feasibility of HIIT breaks to sitting.
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 40 to 75. Healthy volunteers may be eligible.
You may be able to join if
- Age 40-75 years
- BMI \<40 kg/m2
- Sedentary (≥ 6 h/day sitting by a survey question)
- Physically inactive adults based on the CSEP-PATH: Physical Activity and Sedentayr Behaviour Questionnaire (PASB-Q) Adult (low or medium physical...
- Capable of exercising vigorously based on the Physical Activity Readiness Questionnaire (PARQ+)
You likely can't join if
- Physical disability or musculoskeletal disease prohibitive to vigorous exercise
- Learning disabilities
- Cognitive impairment (MoCA \<26)
- Type 1 or 2 diabetes
- Neurological condition (e.g., Multiple Sclerosis, Parkinson, Dementia, Mild Cognitive Impairment)
- Color blindness
See the full eligibility criteria
- Age 40-75 years
- BMI \<40 kg/m2
- Sedentary (≥ 6 h/day sitting by a survey question)
- Physically inactive adults based on the CSEP-PATH: Physical Activity and Sedentayr Behaviour Questionnaire (PASB-Q) Adult (low or medium physical activity range equivalent to less than 300 min of moderate intensity...
- Capable of exercising vigorously based on the Physical Activity Readiness Questionnaire (PARQ+)
- Has a medical clearance for maximal exercise and HIIT from a physician
- Normotensive or participant's blood pressure is controlled
- Intelligence quotient (IQ) ≥85
- Fasting plasma glucose \<126 mg/dL
- Good or corrected vision and hearing
- Right-handed
- No significant abnormalities on the ECG during the maximal exercise test
- No signs and symptoms that suggest an underlying cardiovascular disease as recorded during the maximal exercise test by a study physician.
- No indications to prematurely stop the maximal exercise test as outlined by the ACSM's Guidelines for Exercise Testing and Prescription
- Concussion if more than 12 months before the study screening.
- History of cancer but in full remission for at least 12 months and no history of chemotherapy, signed off by the physician or an oncologist
- Physical disability or musculoskeletal disease prohibitive to vigorous exercise
- Learning disabilities
- Cognitive impairment (MoCA \<26)
- Type 1 or 2 diabetes
- Neurological condition (e.g., Multiple Sclerosis, Parkinson, Dementia, Mild Cognitive Impairment)
- Color blindness
- Brain injury (e.g., traumatic brain injury, stroke, concussion)
- Migraine headaches
- Presence of other health conditions that may be exacerbated by exercise
- History of heart disease
- High cholesterol not controlled by medication
- Signs and symptoms indicative of underlying cardiovascular disease
- A chronic pulmonary disease
- Emphysema
- Pulmonary embolus
- Asthma
- History of renal disease
- History of seizures
- A neuropsychiatric disorder
- Osteoporosis if it interferes with an individual's ability to exercise
- Severe back problems
- Severe arthritis if it interferes with an individual's ability to exercise
- Thyroid disorder not controlled by medication
- Polyneuropathy
- Sleep disorders
- Acquired immunodeficiency syndrome (AIDS)
- Hepatitis C
- History of long Coronavirus Disease 2019 (COVID-19)
- History of cancer if not in full remission for at least 12 months and if a participant had the history of chemotherapy
- Current or past smoking \<12 months
- Corticosteroid intake \< 31 days before screening
- Opioids taken \< 6 months from screening
- Anabolic androgens taken \< 31 days before screening
- A serious illness or hospitalization in the last six months
- Currently taking medications that can affect the central nervous system (except for anxiolytics)
- Current participation in an ongoing trial likely to influence exercise ability or cognitive function
The study team makes the final eligibility decision.
Where it's taking place
- Urbana, Illinois, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 40 years to 75 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Urbana, Illinois, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.