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New treatment option for Chest Pain
Official title Vericiguat in Patients With Coronary Microvascular Dysfunction Causing Stable Chest Pain (V-COM)
ClinicalTrials.gov ID: NCT06239974
What this study is testing
What is Vericiguat?
Vericiguat is an investigational medicine, given as an once-daily, being studied as a potential treatment for chest pain.
Also referred to as Verquvo.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- This is a randomised controlled trial to determine the effectiveness of Vericiguat to improve stress myocardial blood flow (MBF) and myocardial perfusion reserve as measured by cardiac magnetic resonance (CMR) imaging.
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 40 to 75
You may be able to join if
- Stable recurrent chest pain.
- 40 to 75 years old.
- Have coronary computed tomography (CT) angiogram or catheter coronary angiogram within 6 months showing non-obstructive coronary artery disease (\...
- Stress CMR MPR \<2.19 12 or Stress MBF \<2.19ml/g/min 13.
- Female participant is eligible to participate if she is not pregnant or breastfeeding, is not a woman of childbearing potential (WOCBP),or is a WOCBP...
You likely can't join if
- Systolic blood pressure \<100 mm Hg.
- Concurrent use of soluble guanylate cyclase stimulators (eg. Riociguat), or phosphodiesterase type 5 inhibitors (eg. vardenafil, tadalafil, and...
- Has known allergy or sensitivity to any soluble guanylate cyclase stimulator.
- On long-acting nitrates (eg. isosorbide mononitrate)
- Known cardiomyopathy, complex congenital heart disease, endocarditis or pericarditis.
- Has acute coronary syndrome (unstable angina, non-ST elevation myocardial infarction (NSTEMI), or ST elevation myocardial infarction (STEMI)) or...
See the full eligibility criteria
- Stable recurrent chest pain.
- 40 to 75 years old.
- Have coronary computed tomography (CT) angiogram or catheter coronary angiogram within 6 months showing non-obstructive coronary artery disease (\ 0.8).
- Stress CMR MPR \<2.19 12 or Stress MBF \<2.19ml/g/min 13.
- Female participant is eligible to participate if she is not pregnant or breastfeeding, is not a woman of childbearing potential (WOCBP),or is a WOCBP and agrees to follow contraceptive guidance during the study...
- Systolic blood pressure \<100 mm Hg.
- Concurrent use of soluble guanylate cyclase stimulators (eg. Riociguat), or phosphodiesterase type 5 inhibitors (eg. vardenafil, tadalafil, and sildenafil).
- Has known allergy or sensitivity to any soluble guanylate cyclase stimulator.
- On long-acting nitrates (eg. isosorbide mononitrate)
- Known cardiomyopathy, complex congenital heart disease, endocarditis or pericarditis.
- Has acute coronary syndrome (unstable angina, non-ST elevation myocardial infarction (NSTEMI), or ST elevation myocardial infarction (STEMI)) or coronary revascularization (coronary artery bypass grafting (CABG) or...
- Has symptomatic carotid stenosis, transient ischemic attack (TIA) or stroke within 60 days prior to randomisation.
- Estimated glomerular filtration rate (eGFR) \<30 mL/min/1.73m2
- Malignancy or other non-cardiac condition limiting life expectancy to \<3 years.
- Patient's with implanted devices which are not MRI compatible.
The study team makes the final eligibility decision.
Where it's taking place
- Hong Kong, Hong Kong
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 40 years to 75 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Hong Kong, Hong Kong. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.