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New treatment option for Posttraumatic Stress Disorder
Official title A Mechanistic Trial of the Neurobiology of Extinction Learning and Intraparietal Sulcus Stimulation
ClinicalTrials.gov ID: NCT06234969
What this study is testing
- What it's testing
- This study will be the first of its kind to explore the impact of continuous theta burst stimulation (cTBS) to the intraparietal sulcus (IPS) on arousal symptoms among patients with posttraumatic stress disorder (PTSD). The investigators will demonstrate that IPS cTBS results in significant reduction in arousal (measured by startle response) compared to sham cTBS, that IPS cTBS interacts with extinction training to further improve arousal, and that there is a dose/response effect of cTBS on arousal.
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 60
You may be able to join if
- Adult aged 18-60
- Meets Diagnostic and Statistical Manual of Mental Disorders (DSM-5) criteria for PTSD according to the Clinician-Administered PTSD Scale for DSM-5
- No metal implants
You likely can't join if
- Pregnancy
- Seizure disorder or epilepsy
- Increased risk of seizure
- Non-English speaking
- Any medical condition that increases risk for fMRI or cTBS
- Medical implant
See the full eligibility criteria
- Adult aged 18-60
- Meets Diagnostic and Statistical Manual of Mental Disorders (DSM-5) criteria for PTSD according to the Clinician-Administered PTSD Scale for DSM-5
- No metal implants
- Pregnancy
- Seizure disorder or epilepsy
- Increased risk of seizure
- Non-English speaking
- Any medical condition that increases risk for fMRI or cTBS
- Medical implant
- Hearing loss sufficient to interfere with startle
- Claustrophobia
- Recent medication or therapy changes (in the past 8 weeks)
- Current severe substance use disorder
The study team makes the final eligibility decision.
Where it's taking place
- Philadelphia, Pennsylvania, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 60 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Philadelphia, Pennsylvania, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.