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New treatment option for Acute Kidney Injury
Official title Effect of a Furosemide Stress Test-Guided Strategy on Liberation From Continuous Renal Replacement Therapy in Critically Ill Patients With Acute Kidney Injury
ClinicalTrials.gov ID: NCT06229990
What this study is testing
What is Furosemide Injection?
Furosemide Injection is an investigational medicine, given as an infusion into a vein, being studied as a potential treatment for acute kidney injury.
Also referred to as Furosemide stress test.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- Currently, continuous renal replacement therapy (CRRT) is the main modality for renal support in critically ill patients with hemodynamic instability. Most studies have investigated the timing of RRT initiation.
- Phase 4: studies an already-approved treatment
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 20 and older
You may be able to join if
- Adult 20 year of age or older
- Acute kidney injury (AKI) stage 3 according to Kidney Disease Improving Global Outcomes (KDIGO) classification with oliguria (urine \<400 ml/day)
- Initiate CRRT in ICU (medical ICU, surgical ICU, cardiac care unit) for at least 48 hours (time for initiation and modality of CRRT can adjust by...
You likely can't join if
- Use any inotropic drug (norepinephrine, epinephrine, dopamine, dobutamine)
- Blood urea nitrogen (BUN) \>80 mg/dL
- Serum K \ 5 mmol/L
- Arterial potential of Hydrogen (pH) \<7.3
- Serum bicarbonate (HCO3) \<15 mmol/L
- Urine volume \ 2,100 mL/day
See the full eligibility criteria
- Adult 20 year of age or older
- Acute kidney injury (AKI) stage 3 according to Kidney Disease Improving Global Outcomes (KDIGO) classification with oliguria (urine \<400 ml/day)
- Initiate CRRT in ICU (medical ICU, surgical ICU, cardiac care unit) for at least 48 hours (time for initiation and modality of CRRT can adjust by clinician)
- Use any inotropic drug (norepinephrine, epinephrine, dopamine, dobutamine)
- Blood urea nitrogen (BUN) \>80 mg/dL
- Serum K \ 5 mmol/L
- Arterial potential of Hydrogen (pH) \<7.3
- Serum bicarbonate (HCO3) \<15 mmol/L
- Urine volume \ 2,100 mL/day
- Urine creatinine clearance (CrCl) at 6 hours \>20 mL/min
- Previous chronic kidney disease (CKD) stage 5 or estimated glomerular filtration rate (eGFR) \<15 mL/min/1.73 m2
- Previous RRT within 14 days
- Kidney transplantation
- Obstructive etiology for AKI
- Toxin/drug that necessitates RRT
- Allergy to furosemide
- Moribund with expected death within 24 hours
- Pregnancy
The study team makes the final eligibility decision.
Where it's taking place
- Chiang Mai, Thailand
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 20 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Chiang Mai, Thailand. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.