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New treatment option for DMD-Associated Dilated Cardiomyopathy
Official title Modulation of SERCA2a of Intra-Myocytic Calcium Trafficking in Cardiomyopathy Secondary to Duchenne Muscular Dystrophy
ClinicalTrials.gov ID: NCT06224660
What this study is testing
What is SRD-001?
SRD-001 is an investigational medicine, given as an infusion into a vein, being studied as a potential treatment for dmd-associated dilated cardiomyopathy.
Also referred to as AAV1/SSERCA2a.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- This research study is testing whether an experimental drug, called SRD-001, is safe and helps the weakened heart of patients with Duchenne muscular dystrophy (DMD) regain its ability to effectively pump blood to the rest of the body. SRD-001 is a form of gene therapy.
- Phase 1: an early, usually small safety study
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older, men only
You may be able to join if
- Diagnosis of DMD with confirmatory genetic testing
- Cardiomyopathy with left ventricular scar in at least 3 of 16 segments
- Left ventricular ejection fraction \< 40%
- Individualized, optimized cardiac medical therapy and glucocorticoid treatment for at least 12 months prior to enrollment
- Willing and able to provide informed consent
You likely can't join if
- Abnormal blood pressure
- Non-DMD-related liver function test elevations
- Cystatin C ≥ 1.2 mg/L
- Thrombocytopenia
- Anemia
- Inadequate pulmonary function
The study team makes the final eligibility decision.
Where it's taking place
- Kansas City, Kansas, United States
- Cincinnati, Ohio, United States
- Columbus, Ohio, United States
Compensation & support
Compensation mentioned.
ClinicalTrials.gov doesn't provide a reliable structured field for payment or travel support - confirm details with the study team.
Questions & answers
Do participants get paid in this trial?
This study's listing includes signals that participants may be compensated or receive a stipend. Amounts vary and are set by the study team - confirm the details with them.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling male, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Kansas City, Kansas, United States; Cincinnati, Ohio, United States; Columbus, Ohio, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.