BridgeMD
New treatment option for Psychosis
Official title Investigating the Effect of a Single-dose of Levetiracetam on Brain Function, Chemistry and Cognitive Performance in Psychosis Risk
ClinicalTrials.gov ID: NCT06224530
What this study is testing
What is Levetiracetam?
Levetiracetam is an investigational medicine, given as a pill taken by mouth, being studied as a potential treatment for psychosis.
Also referred to as Keppra.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- Background Psychosis is a mental health condition that affects around 3 in 100 people in their lifetime. Most treatments for psychosis target a brain chemical called dopamine but they don't work for everyone and don't address many of the symptoms.
- Time commitment: about 3 months
- You might receive a placebo (an inactive treatment) instead of the study drug, decided by chance. You may not know which one you got.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 40. Healthy volunteers may be eligible.
You may be able to join if
- CHR-P 1. Age range 18-40 years
- Capacity to consent to participation in the study
- Inclusion into attenuated psychosis group as assessed by the CAARMS
- Scores 3-5 on CAARMS unusual thought content or non-bizarre ideas subscales CHR-P
You likely can't join if
- Past episode of psychosis
- Current exposure to drugs with strong GABAergic or glutamatergic effects (benzodiazepines, anticonvulsants, mood stabilisers, zopiclone, zolpidem...
- Current/recent exposure to any antipsychotic medication
- Diagnosis of any neurological disorder, including epilepsy
- Current pregnancy/breastfeeding
- Severe renal impairment
See the full eligibility criteria
- CHR-P 1. Age range 18-40 years
- Capacity to consent to participation in the study
- Inclusion into attenuated psychosis group as assessed by the CAARMS
- Scores 3-5 on CAARMS unusual thought content or non-bizarre ideas subscales CHR-P
- Past episode of psychosis
- Current exposure to drugs with strong GABAergic or glutamatergic effects (benzodiazepines, anticonvulsants, mood stabilisers, zopiclone, zolpidem, ketamine, opiates, atomoxetine, memantine)
- Current/recent exposure to any antipsychotic medication
- Diagnosis of any neurological disorder, including epilepsy
- Current pregnancy/breastfeeding
- Severe renal impairment
- Known allergy to levetiracetam
- Contraindication to MRI scanning
- IQ\<70 as determined with WAIS-III
- CHR-P individuals are not deemed to have a full-blown mental health disorder. However, in the event that a CHR-P individual is acutely ill and lacking capacity to consent, they will not be approached to take part in...
- Age range 18-40 years
- Capacity to consent to participation in the study HC exclusion criteria:
- Personal history of mental health conditions
- Any first-degree relative with a psychotic disorder
- Diagnosis of any neurological disorder, including epilepsy
- Currently pregnant, breastfeeding, or trying to conceive
- Current exposure to drugs with strong GABAergic or glutamatergic effects (benzodiazepines, anticonvulsants, mood stabilisers, zopiclone, zolpidem, ketamine, opiates, atomoxetine, memantine)
- Current/recent exposure to any antipsychotic medication
- Contraindication to MRI scanning
- IQ\<70 as determined with WAIS-III
The study team makes the final eligibility decision.
Where it's taking place
- London, London, United Kingdom
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The study runs about 3 months per participant, based on its public description. The team confirms the exact schedule and number of visits before you enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 40 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include London, London, United Kingdom. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.