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New treatment option for Ischemic Stroke
Official title Oxygen Concentration Target in Stroke Endovascular Treatment
ClinicalTrials.gov ID: NCT06224426
What this study is testing
- What it's testing
- The goal of this clinical trial is to compare the effects of different concentrations of normobaric oxygen on early neurological improvement in acute ischemic stroke (AIS) patients receiving endovascular therapy (EVT). The main questions it aims to answer are: Evaluating the impact of normobaric high-concentration oxygen versus low-concentration oxygen on early neurological function after EVT.
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Age ≥18 years.
- Anterior circulation occlusive stroke is confirmed by CT angiography (CTA), magnetic resonance angiography (MRA) or digital subtraction angiography...
- NIHSS score at admission: 6-20.
- Randomization can be completed within 24 hours after stroke onset.
You likely can't join if
- Stroke onset within 6-24 hours with a CT perfusion imaging (CTP)-assessed mismatched area\<15 ml.
- Presence of anemia, defined as hemoglobin levels o below 120 g/L in men and below 110 g/L in women.
- Pre-stroke modified Rankin scale (mRS) score ≥2.
- Complicated by severe agitation and seizures.
- Evidence of intracranial hemorrhage at admission.
- Presence of chronic obstructive pulmonary disease, asthma, or other respiratory conditions, or requirement for daily supplemental oxygen or...
See the full eligibility criteria
- Age ≥18 years.
- Anterior circulation occlusive stroke is confirmed by CT angiography (CTA), magnetic resonance angiography (MRA) or digital subtraction angiography (DSA), and occlusions of intracranial internal carotid artery (ICA) or...
- NIHSS score at admission: 6-20.
- Randomization can be completed within 24 hours after stroke onset.
- Stroke onset within 6-24 hours with a CT perfusion imaging (CTP)-assessed mismatched area\<15 ml.
- Presence of anemia, defined as hemoglobin levels o below 120 g/L in men and below 110 g/L in women.
- Pre-stroke modified Rankin scale (mRS) score ≥2.
- Complicated by severe agitation and seizures.
- Evidence of intracranial hemorrhage at admission.
- Presence of chronic obstructive pulmonary disease, asthma, or other respiratory conditions, or requirement for daily supplemental oxygen or mechanical ventilation.
- Baseline arterial blood gas analysis indicating impaired gas exchange: PaO2 \< 60 mmHg on room air, or oxygenation index (PaO2/FiO2) \< 300 mmHg with supplemental oxygen.
- Emergency chest CT reveals significant pulmonary parenchymal infection.
- An oxygen mask or ventilator must be used before anesthesia to maintain a SpO2≥94%.
- Loss of airway protective reflex or vomiting aspiration upon admission.
The study team makes the final eligibility decision.
Where it's taking place
- Beijing, Beijing Municipality, China
Compensation & support
Compensation mentioned.
ClinicalTrials.gov doesn't provide a reliable structured field for payment or travel support - confirm details with the study team.
Questions & answers
Do participants get paid in this trial?
This study's listing includes signals that participants may be compensated or receive a stipend. Amounts vary and are set by the study team - confirm the details with them.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Beijing, Beijing Municipality, China. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.