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New treatment option for Lassa Fever
Official title LAssa Fever Adjunct Treatment With DEXamethasone
ClinicalTrials.gov ID: NCT06222723
What this study is testing
What is Dexamethasone?
Dexamethasone is an investigational medicine, given as an infusion into a vein, being studied as a potential treatment for lassa fever.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- Dexamethasone is a corticosteroid which can modulate inflammatory-mediated tissue damage associated with a wide range of infectious diseases. Dexamethasone is routinely used for treatment of tuberculous meningitis and for pneumococcal meningitis in adults.
- Phase 2: a mid-size study of how well it works
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Age ≥ 18 years
- LF confirmed by RT-PCR (reverse-transcription polymerase chain reaction) with a cycle threshold (Ct) value \< 30
- Signs of significant health impairment as evidenced by any of the following:
- Alert, confusion, voice, pain, unresponsive (ACVPU) other than A
- Systolic blood pressure \< 90 mmHg
You likely can't join if
- Pregnancy (evidenced by positive urine pregnancy test in women of child-bearing potential)
- Lactation following live birth
- Known intolerance and contra-indications to ribavirin or dexamethasone
- Patients who already received a corticosteroid within the preceding 7 days
- Investigator's valuation that patient might be put to substantial risk by participating in this trial
- Patients receiving end-of-life care as judged by the investigator
See the full eligibility criteria
- Age ≥ 18 years
- LF confirmed by RT-PCR (reverse-transcription polymerase chain reaction) with a cycle threshold (Ct) value \< 30
- Signs of significant health impairment as evidenced by any of the following:
- Alert, confusion, voice, pain, unresponsive (ACVPU) other than A
- Systolic blood pressure \< 90 mmHg
- Seizure(s), meningism, coma, focal neurological deficit
- AST (GOT) \>3xULN
- ALT (GPT) \> 3xULN
- KDIGO 2 or more severe based on serum creatinine only
- Active macroscopic bleeding
- O2 saturation \< 92
- Pregnancy (evidenced by positive urine pregnancy test in women of child-bearing potential)
- Lactation following live birth
- Known intolerance and contra-indications to ribavirin or dexamethasone
- Patients who already received a corticosteroid within the preceding 7 days
- Investigator's valuation that patient might be put to substantial risk by participating in this trial
- Patients receiving end-of-life care as judged by the investigator
The study team makes the final eligibility decision.
Where it's taking place
- Irrua, Edo, Nigeria
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Irrua, Edo, Nigeria. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.