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New treatment option for Resistant Hypertension
Official title A First-in-human Study of HyperQureTM", Laparoscopic Renal Denervation Therapy in Patient With Resistant Hypertension
ClinicalTrials.gov ID: NCT06216808
What this study is testing
- What it's testing
- HQ-HTN-K01-02 is a prospective, multicenter, single arm, open label, first-in-human study to evaluate the safety and initial efficacy of HyperQureTM, laparoscopic denervation therapy, in patients with resistant hypertension on 3 or more antihypertensive medications
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 19 to 79
You may be able to join if
- people are deemed eligible for this clinical trial only if they meet all of the following criteria:
- Male and female patients aged between 19 and 79 years old
- Resistant hypertensive patients on stable regimen of at least 3 antihypertensive medications\ for at least 4weeks prior Screening1 and those who are...
- Patients on at least 3 antihypertensive medications of different classes including diuretics
- Those who meet the following blood pressure requirements: [Screening 1]
You likely can't join if
- people cannot be enrolled in the clinical trial if they meet any of the following criteria
- Those with the following confirmed anatomical findings in the kidney or renal artery that are unsuitable for renal denervation (assessed based on the...
- If there is an atheroma or renal artery stent within 5 mm of the renal denervation site
- Presence of stenosis of 30% or more on all of the blood vessels available for renal denervation therapy
- When it is deemed impossible to perform denervation on both renal arteries according to the discretion of the investigator
- Those with a medical history or a history of surgery/procedure that is unsuitable for renal denervation therapy
See the full eligibility criteria
Who can join
- people are deemed eligible for this clinical trial only if they meet all of the following criteria:
- Male and female patients aged between 19 and 79 years old
- Resistant hypertensive patients on stable regimen of at least 3 antihypertensive medications\ for at least 4weeks prior Screening1 and those who are willing to continue existing antihypertensive medications during run-...
- Patients on at least 3 antihypertensive medications of different classes including diuretics
- Those who meet the following blood pressure requirements: [Screening 1]
- Office systolic blood pressure (SBP) ≥ 140 mmHg
- Office diastolic blood pressure (SBP) ≥ 90 mmHg [Screening 2]
- Office SBP ≥ 140 mmHg
- Office DBP ≥ 90 mmHg
- Daytime ASBP ≥ 135 mmHg
- Those who have the ability and willingness to provide voluntary and written consent to participate in this clinical trial
What rules you out
- people cannot be enrolled in the clinical trial if they meet any of the following criteria
- Those with the following confirmed anatomical findings in the kidney or renal artery that are unsuitable for renal denervation (assessed based on the results of the renal CT angiography of Screening 2)
- If there is an atheroma or renal artery stent within 5 mm of the renal denervation site
- Presence of stenosis of 30% or more on all of the blood vessels available for renal denervation therapy
- When it is deemed impossible to perform denervation on both renal arteries according to the discretion of the investigator
- Those with a medical history or a history of surgery/procedure that is unsuitable for renal denervation therapy
- Renal denervation therapy
- Renal artery stenting within 3 months prior to surgery
- Polycystic kidney disease (PKD)
- Atrophic kidney
- Kidney transplant
- Dialysis due to end-stage renal disease
- Any surgery performed on the both kidney
- FMD(Fibromuscular dysplasia)
- Those with a confirmed comorbidity or a history of surgery/procedure that is unsuitable for posterior retroperitoneal approach required for renal denervation therapy
- Surgical history using the retroperitoneal approach
- Fibrosis of the retroperitoneal region
- Inflammation of the retroperitoneal region
- Extreme obesity (body mass index (BMI) \> 40 kg/m2)
- Risk of elevated intracranial pressure
- eGFR\ \< 45 mL/min/1.73 m2
- eGFR calculation formula (MDRD equation) 175 × (sCr)-1.154 × (age)-0.203 × (0.742 if female)
- Those with type 1 diabetes or uncontrolled type 2 diabetes\
- Uncontrolled type 2 diabetes: HbA1c ≥ 8.0%
- HbA1c will be tested in Screening 2 if the confirmed HbA1c result is from the test conducted 3 months before Screening 2 or if additional tests are deemed necessary according to the investigator discretion due to a...
- Those who receive SGLT2 inhibitors or GLP-1 agonists within 90 days before Screening 1, or those who are expected to require treatment during the clinical trial period(but if on continuous medication without changes...
- Those with at least a 20-mmHg decrease in office SBP or at least a 10-mmHg decrease in office DBP accompanied by symptoms, measured within 3 minutes of standing up during Screening 2(but if orthostatic hypotension is...
- Those who are likely to experience safety problems due to blood pressure drop according to the discretion of the investigator (e.g., heart valve stenosis, peripheral vascular disease, aortic aneurysm, and high-risk...
- Those who have difficulty in measuring blood pressure accurately according to the discretion of the investigator (e.g., if the circumference of the upper arm is larger than the cuff size of the blood pressure monitor...
- Those who have secondary hypertension or are receiving sympathomimetic drugs that affect hypertension
- Those with a history of the following cardiovascular diseases or accompanying diseases
- Myocardial infarction occurring within 3 months prior to Screening 1
- Stable/Unstable angina occurring within 3 months prior to Screening 1
- Heart failure(NYHA classification III\~IV) within 3 months prior to Screening 1
- Transient ischemic attack within 3 months prior to Screening 1
- Cerebrovascular seizures (e.g., subarachnoid hemorrhage, cerebral embolism, etc.) within 3 months prior to Screening 1
- Atrial fibrillation (except for those who have confirmed sinus rhythm after undergoing medicinal treatment or surgery such as catheterization for the treatment of atrial fibrillation)
- Those with primary pulmonary hypertension
- Those with confirmed bleeding diathesis, coagulation disorder, or refusal to receive transfusions
- Those with a history of peptic ulcer disease or gastrointestinal bleeding within 6 months prior to Screening 1
- Those who are chronically on oxygen-assisted or mechanical ventilation (e.g., CPAP, BiPAP) (however, usage due to sleep apnea is exempted)
- Those who have taken non-steroidal anti-inflammatory drugs (NSAIDs) twice or more per week for pain control within 1 month prior to Screening 2
- Those with a history of contraindications to the use of contrast agents, anaphylactic reactions, or uncontrolled allergic reactions
- Those receiving antiretroviral drug therapy due to HIV infection (except when there is a documented history of hypertension prior to initiation of antiretroviral drug therapy)
- Those with the following confirmed drug administration history in relation to narcotic drugs:
- A history of abuse of narcotic drugs
- Those who use methadone
- Those who have used narcotic drugs twice or more within 1 month prior to Screening 1
- Those with drug or alcohol dependence that has not been cured at the time of Screening 1, and who lack the ability or are unable to understand and follow the instructions required in this clinical trial
- Those who are scheduled to undergo a surgery/procedure that is expected to affect the how well it works and safety of this clinical trial according to the discretion of the investigator
- Night shift workers
- Those who have received other investigational products or investigational medical devices within 4 weeks prior to Screening 1 (however, such patients may be enrolled if such products of devises do not affect the how...
- Women who are pregnant, lactating, or plan to become pregnant during the period of the clinical trial
- Other people who are deemed ineligible to participate in this clinical trial according to the investigator's discretion
The study team makes the final eligibility decision.
Where it's taking place
- Jeonam, Chonnam Province, South Korea
- Gyeonggi-do, South Korea
- Seoul, South Korea
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 19 years to 79 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Jeonam, Chonnam Province, South Korea; Gyeonggi-do, South Korea; Seoul, South Korea. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.