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Tests treatment safety and results for Melanoma Stage III
Official title To Evaluate the Safety and Efficacy of ADP-TILIL7 in Patients With Locally Advanced or Metastatic Melanoma
ClinicalTrials.gov ID: NCT06204991
What this study is testing
What is ADP-TILIL7?
ADP-TILIL7 is an investigational medicine, given as an infusion into a vein, being studied as a potential treatment for melanoma stage iii.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- The primary objective of this Phase 1 clinical trial is to evaluate the feasibility and tolerability of a novel generation of gene-modified tumor infiltrating lymphocytes (TILs) in a cohort of 10 patients aged 18-75 diagnosed with unresectable or metastatic melanoma. TILs will undergo transduction with the Interleukin-7 (IL-7) gene, for IL-7 production upon antigen engagement.
- Phase 1: an early, usually small safety study
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 75
You may be able to join if
- All the criteria listed in the following need to be met before patient inclusion.
- Histologically confirmed inoperable or metastatic melanoma (stage IIIc or IV).
- Progressive disease after standard treatment with PD-1 check-point inhibition or combination of aforementioned with CTLA-4 check-point inhibition.
- Age: 18 - 75 years at time of signed Informed consent.
- ECOG performance status of ≤ 1 (Appendix 2).
You likely can't join if
- Patients will be excluded if they meet one of the criteria's listed below
- Subject has received or plans to receive the following therapy/treatment prior to tumor resection (TR) or lymphodepleting chemotherapy (LDC):
- Cytotoxic chemotherapy: Washout period 3 weeks before TR and LDC
- Small molecules/TKI: Washout period 1 week before TR and LDC
- Immune therapy (monoclonal AB therapy, CPI and biologics): 2 weeks before TR and LDC
- Prior T-cell therapy, including gene therapy using an integrating vector
See the full eligibility criteria
Who can join
- All the criteria listed in the following need to be met before patient inclusion.
- Histologically confirmed inoperable or metastatic melanoma (stage IIIc or IV).
- Progressive disease after standard treatment with PD-1 check-point inhibition or combination of aforementioned with CTLA-4 check-point inhibition.
- Age: 18 - 75 years at time of signed Informed consent.
- ECOG performance status of ≤ 1 (Appendix 2).
- Is fit for tumor resection and has at least one lesion (\> 1 cm3) available for surgical resection for manufacture of TIL.
- At least one measurable parameter in accordance with RECIST 1.1 -criteria (excluding lesion to be resected).
- LVEF assessment with documented LVEF ≥50% by either TTE (transthoracic echocardiography) or MUGA (multigated acquisition scan).
- Sufficient organ function, including:
- Absolute neutrophil count (ANC) ≥ 1.500 /µl
- Leucocyte count ≥ lower normal limit
- Platelets ≥ 100.000 /µl and \<700.000 /µl
- Hemoglobin ≥ 6.0 mmol/l
- eGFR \> 70 ml/min\
- S-bilirubin ≤ 1.5 times upper normal limit (Exception: people with liver metastasis ≤ 2.5 × ULN)
- ASAT/ALAT ≤ 2.5 times upper normal limit (Exception: people with liver metastasis ≤ 5.0 × ULN)
- Alkaline phosphatase ≤ 5 times upper normal limit
- Lactate dehydrogenase ≤ 5 times upper normal limit
- Sufficient coagulation: APPT\<40 and INR\<1.5
- \ In selected cases it can be decided to include a patient with an eGFR \< 70 ml/min with the use of a reduced dose of chemotherapy. 9\. Signed statement of consent after receiving oral and written study information 10...
- Bridging therapy is discouraged. However, if in the opinion of the Investigator, the subject requires immediate therapy after tumor resection, the subject may receive bridging therapy for the period during which the...
- Following this bridging therapy, the subject must adhere to the mandatory washout periods (exclusion criterion 1) and must continue to have measurable disease prior to receiving T-cell therapy. 12\. Age and Reproductive...
- Women of childbearing potential (WOCBP) must have a negative urine or serum pregnancy test AND must agree to use an effective method of contraception starting at the first dose of chemotherapy for at least 12 months...
- Hormonal anticonception (birth control pills, spiral, depot injection with gestagen, subdermal implantation, hormonal vaginal ring and transdermal depot patch)
- Intrauterine device
- Surgical sterilization
- Surgical sterilization of male partner with verification of no sperm after the procedure
- Menopause (for more than 12 months) o Male people must be surgically sterile or agree to use a double-barrier contraception method or abstain from sexual activity with an WOCBP starting at the first dose of chemotherapy...
What rules you out
- Patients will be excluded if they meet one of the criteria's listed below
- Subject has received or plans to receive the following therapy/treatment prior to tumor resection (TR) or lymphodepleting chemotherapy (LDC):
- Cytotoxic chemotherapy: Washout period 3 weeks before TR and LDC
- Small molecules/TKI: Washout period 1 week before TR and LDC
- Immune therapy (monoclonal AB therapy, CPI and biologics): 2 weeks before TR and LDC
- Prior T-cell therapy, including gene therapy using an integrating vector
- Corticosteroids at dose equivalent \> 10 mg prednisone or any other immunosuppressive therapy. 2 weeks before TR and LDC. Note: Use of topical steroids is not an exclusion
- Investigational treatment: 4 weeks or 5 half-lives, whichever is shorter before TR and LDC
- Radiation to the pelvis and/or multiple bones containing ≥ 25% of bone marrow: 4 weeks before TR and LDC
- Whole brain radiotherapy or brain stereotactic radiosurgery: 4 weeks before TR and LDC
- Radiotherapy to the target lesions: 3 months prior to TIL-infusion. A lesion with unequivocal progression post-radiotherapy may be considered a target lesion.
- A history of prior malignancies. Patients treated for another malignancy can participate if they are without signs of disease for a minimum of 2 years after treatment. people with curatively treated ductal carcinoma in...
- Patients with metastatic ocular/mucosal or other non-cutaneous melanoma. Unknown primary melanoma is eligible.
- Toxicity from previous anti-cancer therapy must have resolved to ≤ Grade 1 or baseline prior to enrollment (except for non-clinically significant toxicities e.g., alopecia, vitiligo). people with Grade 2 toxicities who...
- Patients who have more than 2 CNS metastases or who have any CNS lesion that is symptomatic, greater than 1 cm in diameter or show significant surrounding edema on MRI scan will not be eligible until they have been...
- The following patients will be excluded because of inability to receive high dose interleukin-2:
- History of coronary revascularization
- Patients with clinically significant atrial and/or ventricular arrhythmias including but not limited to: atrial fibrillation, ventricular tachycardia, 2o or 3o heart block
- Documented FEV-1 less than or equal to 60% predicted value for patients with: A prolonged history of cigarette smoking (greater than 20 pack years), large tumor burden in the lungs or Symptoms of respiratory distress.
- Known hypersensitivity to one of the active drugs or one or more of the excipients.
- Severe medical conditions, such as severe asthma/COLD, significant cardiac disease, poorly regulated insulin dependent diabetes mellitus among others.
- Acute/chronic infection with HIV, hepatitis, syphilis among others.
- Severe allergies or previous anaphylactic reactions.
- Active autoimmune or immune-mediated disease that has not yet resolved. people with the following will be eligible:
- Immune-mediated AEs secondary to immunotherapy which has resolved to ≤ Grade 1 off steroids;
- Hypothyroidism, Type I diabetes, adrenal insufficiency, or pituitary insufficiency that are stable on replacement therapy;
- Disorders such as asthma, vitiligo, psoriasis, or atopic dermatitis that are well controlled without requiring systemic immunosuppression;
- Other stable immune conditions that do not require prednisone higher than 10 mg/day or their equivalent dose for other corticosteroid agents may be acceptable with the agreement of the Sponsor.
- Pregnant women and women breastfeeding.
- Subject who, in the opinion of the Investigator, will be unlikely to fully comply with protocol requirements.
The study team makes the final eligibility decision.
Where it's taking place
- Herlev, Denmark
Compensation & support
Compensation mentioned.
ClinicalTrials.gov doesn't provide a reliable structured field for payment or travel support - confirm details with the study team.
Questions & answers
Do participants get paid in this trial?
This study's listing includes signals that participants may be compensated or receive a stipend. Amounts vary and are set by the study team - confirm the details with them.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 75 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Herlev, Denmark. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.