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New treatment option for Cocaine Dependence
Official title Effect of HF rTMS on Serum BDNF in Cocaine Use Disorder
ClinicalTrials.gov ID: NCT06189690
What this study is testing
- What it's testing
- This study aims to explore the effect of 5-Hz rTMS over the left dorsolateral prefrontal cortex on the BDNF, craving and cognitive function. This study will be longitudinal, with a short-term double-blind placebo-controlled phase consisting of 20 rTMS sessions and a long-term phase, consisting of 2 weekly sessions for 12 weeks.
- You might receive a placebo (an inactive treatment) instead of the study drug. You may not know which one you got.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 50
You may be able to join if
- Current cocaine use disorder according to the Diagnostic and statistical manual of mental disorders (DSM 5).
- Cocaine crack or powder use for at least 12 months with a frequency of 3 times or more per week, with abstinence periods shorter than 1 year for the...
- Primary school completed.
You likely can't join if
- Personal or first degree family history of any neurological disorder including, but not limited to, organic brain syndrome, epilepsy, brain injuries...
- Personal history of brain surgery or traumatic brain injury.
- Comorbilities that could represent a risk of neuroinfection or increased convulsive threshoid.
- Other than alcohol, tobacco or marijuana substance use disorder.
- If the patient does not meet the safety criteria for rTMS.
- Current use of any medication that might provoque seizures or any anticonvulsant drugs.
See the full eligibility criteria
- Current cocaine use disorder according to the Diagnostic and statistical manual of mental disorders (DSM 5).
- Cocaine crack or powder use for at least 12 months with a frequency of 3 times or more per week, with abstinence periods shorter than 1 year for the last year.
- Primary school completed.
- Personal or first degree family history of any neurological disorder including, but not limited to, organic brain syndrome, epilepsy, brain injuries, multiple sclerosis, conditions that increase intracranial pressure.
- Personal history of brain surgery or traumatic brain injury.
- Comorbilities that could represent a risk of neuroinfection or increased convulsive threshoid.
- Other than alcohol, tobacco or marijuana substance use disorder.
- If the patient does not meet the safety criteria for rTMS.
- Current use of any medication that might provoque seizures or any anticonvulsant drugs.
- Personal history of schizophrenia, mania/hypomania or OCD.
- Personal history of myocardial infarction, angina, congestive heart failure, cerebrovascular events, transient ischemic attack or any other heart condition currently undergoing medical treatment.
- Personal history of seizures or detection of paroxysmal EEG activity.
The study team makes the final eligibility decision.
Where it's taking place
- Mexico City, Tlalpan, Mexico
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 50 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Mexico City, Tlalpan, Mexico. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.