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Official title EEG-fMRI Experiments During Anesthesia Induction With Propofol
ClinicalTrials.gov ID: NCT06179719
What this study is testing
What is Propofol?
Propofol is an investigational medicine, given as an infusion into a vein, being studied as a potential treatment for anesthesia.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- This observational study aims to investigate healthy cortical and subcortical neural processes involved in generating intrinsic alpha oscillations during induction of general anesthesia with propofol. To do this, the investigators have designed a simultaneous electroencephalogram (EEG)- MRI (functional MRI and Spectroscopy) experiment with a visual stimulation paradigm that addresses the subject's specific intrinsic alpha rhythm during anesthesia and wakefulness.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 35. Healthy volunteers may be eligible.
You may be able to join if
- Female and male healthy individuals (ASA I: assessed according to the American Society of Anesthesiologists Physical Status Classification System a...
- Age: 18 to 35 years
- Capacity to give consent
- Written consent after detailed information.
You likely can't join if
- Individuals who do not meet all inclusion criteria
- Previous brain surgery
- History of epileptic seizures
- History of psychiatric or neurological disease
- Physical status other than American Society of Anesthesiologists physical status I, e.g., presence of severe internal or systemic disease
- Chronic intake of medication or drugs (Alcohol, Marihuana, Cocaine, Opioids, Benzodiazepine, etc.)
See the full eligibility criteria
- Female and male healthy individuals (ASA I: assessed according to the American Society of Anesthesiologists Physical Status Classification System a non-acute or chronic disease), non-pregnant, non-smokers...
- Age: 18 to 35 years
- Capacity to give consent
- Written consent after detailed information.
- Individuals who do not meet all inclusion criteria
- Previous brain surgery
- History of epileptic seizures
- History of psychiatric or neurological disease
- Physical status other than American Society of Anesthesiologists physical status I, e.g., presence of severe internal or systemic disease
- Chronic intake of medication or drugs (Alcohol, Marihuana, Cocaine, Opioids, Benzodiazepine, etc.)
- Impaired hearing or presence of deafness
- Absence of fluency in the German language
- Known disposition to malignant hyperthermia
- Previous diagnosis of hepatic porphyria
- Body mass index greater than 30 kg/m2
- Gastrointestinal disorders with a disposition for gastroesophageal regurgitation
- Known or suspected difficult airway
- Known hypersensitivity to propofol or any propofol injectable emulsion components (i.e., eggs, eggs products, soybeans, or soy products)
- Atopy/severe allergies/asthma
- Cardiological abnormalities: torsades de pointes, prolonged QT interval, QT changes present since birth.
- Contraindications to MRI (e.g., pacemakers, artificial heart valves, cardioseal, aneurysm clips, implanted magnetic metal parts (screws, plates from surgery), cochlear implants, metal splitters/grenade splinters...
- Pregnancy
- people with claustrophobia
The study team makes the final eligibility decision.
Where it's taking place
- Munich, Bavaria, Germany
- München, München (Stadt), Germany
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 35 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Munich, Bavaria, Germany; München, München (Stadt), Germany. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.