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Compares treatment options for Prosthetic-joint Infection
Official title Rifampicin Combination Therapy Versus Monotherapy for Staphylococcal Prosthetic Joint Infection
ClinicalTrials.gov ID: NCT06172010
What this study is testing
What is Clindamycin?
Clindamycin is an investigational medicine, given as an infusion into a vein, being studied as a potential treatment for prosthetic-joint infection.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- In this Dutch multicenter clinical trial, patients with a staphylococcal prosthetic joint infection, will, in the oral antibiotic treatment phase, be randomized between clindamycin monotherapy and rifampicin / levofloxacin combination therapy. The clinical endpoint will be treatment success one year after finishing antimicrobial treatment.
- Phase 4: studies an already-approved treatment
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- \>18 years of age
- Confirmed staphylococcal prosthetic hip or knee joint infection according to the current EBJIS 2021 definition of PJI
- The causative agents are (or include) S. aureus or and/or Coagulase-negative staphylococci (CNS)
- Treatment is according to the DAIR-procedure
You likely can't join if
- (i) a contra-indication for rifampicin (e.g. a resistant strain or proven allergic reaction or difficult drug-drug-interactions) (ii) complicated S...
The study team makes the final eligibility decision.
Where it's taking place
- Leiden, Zuid Hollans, Netherlands
- Amsterdam, Netherlands
- Groningen, Netherlands
- Hoofddorp, Netherlands
- Leeuwarden, Netherlands
- Leiderdorp, Netherlands
- Nijmegen, Netherlands
- Rotterdam, Netherlands
- Tilburg, Netherlands
- Zwolle, Netherlands
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Leiden, Zuid Hollans, Netherlands; Amsterdam, Netherlands; Groningen, Netherlands; Hoofddorp, Netherlands; Leeuwarden, Netherlands; Leiderdorp, Netherlands and 4 more location(s). Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.