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New treatment option for Nosocomial Pneumonia
Official title High-dose Inhalations of Nitric Oxide in the Treatment of Pneumonia
ClinicalTrials.gov ID: NCT06170372
What this study is testing
What is 200 ppm Nitric Oxide?
200 ppm Nitric Oxide is an investigational medicine, given as an once-daily inhaled treatment, being studied as a potential treatment for nosocomial pneumonia.
Also referred to as nitrogen monoxide.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- This is a multicenter, prospective randomized controlled trial. At least 2 but no more than 5 centers are expected to participate in the study.
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- An established diagnosis of Nosocomial Pneumonia (NP) after cardiac surgery under cardiopulmonary bypass (CPB) or hospitalization for...
- Spontaneous breathing.
- Age \> 18 years.
- Signed informed consent.
- Negative result of immunochromatographic Severe acute respiratory syndrome-related coronavirus 2 rapid antigen test on the day of diagnosis of...
You likely can't join if
- Diagnosed infectious process of another localization (surgical site infection (SSI), acute and chronic urinary tract infection (active)...
- Mechanical ventilation
- Presence of tracheostomy
- Patient's participation in another clinical trial at the time of screening or within the previous 3 months.
- Concomitant pulmonary disease with the need for respiratory support before the development of pneumonia.
- History of malignancy or other irreversible diseases/conditions with a life expectancy of less than 1 year.
See the full eligibility criteria
- An established diagnosis of Nosocomial Pneumonia (NP) after cardiac surgery under cardiopulmonary bypass (CPB) or hospitalization for Community-acquired pneumonia (CAP).
- Spontaneous breathing.
- Age \> 18 years.
- Signed informed consent.
- Negative result of immunochromatographic Severe acute respiratory syndrome-related coronavirus 2 rapid antigen test on the day of diagnosis of pneumonia. Diagnostic criteria for NP The diagnosis of NP is considered...
- acute fever at the onset of the disease (t° \> 38.0°C);
- cough with sputum;
- physical signs (crepitus/fine rales, bronchial breathing, shortening of percussion sound);
- leukocytosis \> 10x109/l and/or left shift (\> 10%)
- Diagnosed infectious process of another localization (surgical site infection (SSI), acute and chronic urinary tract infection (active), catheter-related bloodstream infection, peritonitis, infective endocarditis etc.).
- Mechanical ventilation
- Presence of tracheostomy
- Patient's participation in another clinical trial at the time of screening or within the previous 3 months.
- Concomitant pulmonary disease with the need for respiratory support before the development of pneumonia.
- History of malignancy or other irreversible diseases/conditions with a life expectancy of less than 1 year.
- Presence of HIV infection
The study team makes the final eligibility decision.
Where it's taking place
- Tomsk, Select..., Russia
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Tomsk, Select..., Russia. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.