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New treatment option for Phantom Limb Pain
Official title TITAN Trial: Reducing Phantom Limb Pain in People with Amputations
ClinicalTrials.gov ID: NCT06167330
What this study is testing
- What it's testing
- The goal of this clinical trial is to investigate the effectiveness of two rehabilitation programs for individuals who have undergone amputations and are experiencing phantom limb pain. The main question it aims to answer is: \- In individuals who have undergone amputations and are experiencing phantom limb pain, what is the effectiveness of a progressive rehabilitation program compared to a treatment program consisting of transcutaneous electrical nerve stimulation and cranial electrical stimulation on reducing pain intensity and pain interference?
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Experiencing phantom limb pain for at least three months.
- Report at least one episode of phantom limb pain in the previous week.
- Report at least 4 points in pain intensity over the previous 7 days, assessed using the 11-point Numerical Pain Rating Scale.
- Be a resident in Australia for the intervention and follow-up period.
- Have access to the internet and smart device (e.g., mobile phone).
You likely can't join if
- Bilateral amputation.
- Scheduled for major surgery during the study period.
- Pain in the intact limb.
- Vision impairment that would preclude successful participation.
- Auditory impairment that would preclude successful participation.
- Cognitive problems that would preclude effective participation in trial procedures (e.g., Alzheimer's, dementia).
See the full eligibility criteria
- Experiencing phantom limb pain for at least three months.
- Report at least one episode of phantom limb pain in the previous week.
- Report at least 4 points in pain intensity over the previous 7 days, assessed using the 11-point Numerical Pain Rating Scale.
- Be a resident in Australia for the intervention and follow-up period.
- Have access to the internet and smart device (e.g., mobile phone).
- Be proficient in English.
- Bilateral amputation.
- Scheduled for major surgery during the study period.
- Pain in the intact limb.
- Vision impairment that would preclude successful participation.
- Auditory impairment that would preclude successful participation.
- Cognitive problems that would preclude effective participation in trial procedures (e.g., Alzheimer's, dementia).
- Previously diagnosed neurological disorders that affect the movement of the intact limb (e.g., stroke, Parkinson, Multiple Sclerosis).
- Completed Graded Motor Imagery in the order of left/right judgements, imagined movements, and mirror therapy.
- Have contraindications for the use of stimulation devices (e.g., pacemaker, spinal cord stimulator).
The study team makes the final eligibility decision.
Where it's taking place
- Randwick, New South Wales, Australia
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Randwick, New South Wales, Australia. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.