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Compares treatment options for Guillain-Barre Syndrome
Official title Ventilator Trigger Sensitivity Adjustment Versus Threshold Inspiratory Muscle Training on Arterial Blood Gases
ClinicalTrials.gov ID: NCT06167239
What this study is testing
- What it's testing
- The aim of the current study is to compare the effect of ventilator trigger sensitivity adjustment versus threshold inspiratory muscle training on arterial blood gases in mechanically ventilated patients.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 20 to 55
You may be able to join if
- Difficult to wean Guillain barre patients who have been on MV for at least 48 hours. Difficult to wean people have been defined as those who fail the...
- Age: \>18 years.
- Both sexes will be included.
- Ventilator mode: Pressure support mode with FiO2≤ 0.5, positive end expiratory pressure (PEEP) will be\<8-10cm/H2Oand respiratory rate \< 25.
- Conscious oriented patient with Glasgow coma score ≥13.
You likely can't join if
- Persistent hemodynamic instability as life threatening arrhythmias, acute heart failure.
- Severe breathlessness, when spontaneously breathing.
- Any progressive neuromuscular disease that would interfere with responding to inspiratory muscle training (non-stationary course).
- Spinal cord injury.
- Skeletal pathology (scoliosis, flail chest, spinal instrumentation) that would seriously impair the movement of the chest wall and ribs.
- Patients on heavy sedation and respiratory muscle paralysis.
See the full eligibility criteria
- Difficult to wean Guillain barre patients who have been on MV for at least 48 hours. Difficult to wean people have been defined as those who fail the first spontaneous breathing trial (SBT)and may require up to 3 SBTs...
- Age: \>18 years.
- Both sexes will be included.
- Ventilator mode: Pressure support mode with FiO2≤ 0.5, positive end expiratory pressure (PEEP) will be\<8-10cm/H2Oand respiratory rate \< 25.
- Conscious oriented patient with Glasgow coma score ≥13.
- Alertness will be titrated to a Riker Sedation Agitation Score of 4.
- PH\>7.25, arterial oxygen saturation \>90%.
- Cardiovascular stability.
- Maximal inspiratory pressure from 15 to 30 cm H2O and able to trigger spontaneous breaths on ventilator.
- Persistent hemodynamic instability as life threatening arrhythmias, acute heart failure.
- Severe breathlessness, when spontaneously breathing.
- Any progressive neuromuscular disease that would interfere with responding to inspiratory muscle training (non-stationary course).
- Spinal cord injury.
- Skeletal pathology (scoliosis, flail chest, spinal instrumentation) that would seriously impair the movement of the chest wall and ribs.
- Patients on heavy sedation and respiratory muscle paralysis.
- High peak airway pressure (barotraumas).
- BMI ≥ 40.
The study team makes the final eligibility decision.
Where it's taking place
- Cairo, Egypt
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 20 years to 55 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Cairo, Egypt. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.