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Compares treatment options for Emergency Contraception
Official title Etonogestrel (ENG) Implant Insertion for Emergency Contraception With Oral Levonorgestrel (LNG) vs Placebo
ClinicalTrials.gov ID: NCT06162611
What this study is testing
What is Etonogestrel implant with Oral Levonorgestrel emergency contraception 1.5mg?
Etonogestrel implant with Oral Levonorgestrel emergency contraception 1.5mg is an investigational medicine, given as a pill taken by mouth, being studied as a potential treatment for emergency contraception.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- Intrauterine devices (IUDs) are highly effective to prevent pregnancy when used for emergency contraception (following unprotected intercourse in the last 3 days), but data are lacking for people who desire an etonogestrel (ENG) contraceptive implant in this situation. This proposal will identify the most effective way to start an implant for emergency contraception using a randomized controlled trial comparing pregnancy risk between those receiving the implant vs.
- Phase 4: studies an already-approved treatment
- You might receive a placebo (an inactive treatment) instead of the study drug, decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 35, women only. Healthy volunteers may be eligible.
You may be able to join if
- Between 18-35 years old
- Unprotected intercourse within 72 hours
- Biologically capable of pregnancy (intact uterus without prior sterilization surgery
- Fluent in English and/or Spanish
- Have a regular menstrual cycle (21-35 days)
You likely can't join if
- Current pregnancy (+urine pregnancy test in clinic)
- Breastfeeding
- Contraindication to ENG or LNG based on CDC MEC/SPR
- Sterilization, hysterectomy, or has an IUD or contraceptive implant in place
- Vaginal bleeding of unknown etiology
- Previous use of EC in same cycle
See the full eligibility criteria
- Between 18-35 years old
- Unprotected intercourse within 72 hours
- Biologically capable of pregnancy (intact uterus without prior sterilization surgery
- Fluent in English and/or Spanish
- Have a regular menstrual cycle (21-35 days)
- Known last menstrual period (+/- 3 days)
- Working (cell) phone number
- Willing to comply with the study requirements
- Willing to abstain from any CYP3A4 inducer for 5 days
- Current pregnancy (+urine pregnancy test in clinic)
- Breastfeeding
- Contraindication to ENG or LNG based on CDC MEC/SPR
- Sterilization, hysterectomy, or has an IUD or contraceptive implant in place
- Vaginal bleeding of unknown etiology
- Previous use of EC in same cycle
- Allergy to LNG or ENG
- History of intolerance/ side effects with ENG Implant
- Current (past 7 days) use of any CYP3A4 inducer
- Plan to use any other steroid hormone in the next 4 weeks (testosterone, estrogen, progesterone)
- Ended a pregnancy at or under 20 weeks gestational age within last 2 weeks
- Ended a pregnancy over 20 weeks gestational age in last 6 weeks
- Use of any injectable hormonal contraceptive (Depo-Provera) in the last 15 weeks
- Use of any oral EC, contraceptive pills, patches, vaginal rings, or an IUD or Implant in the last 2 weeks
The study team makes the final eligibility decision.
Where it's taking place
- Salt Lake City, Utah, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling female, 18 years to 35 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Salt Lake City, Utah, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.