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New treatment option for E-cigarette Use
Official title Sex Differences in the Vascular Effects of E-cigarette Use
ClinicalTrials.gov ID: NCT06159608
What this study is testing
What is Local heating + L-NAME (NG-nitro-L-arginine methyl ester; nitric oxide synthase inhibitor)?
Local heating + L-NAME (NG-nitro-L-arginine methyl ester; nitric oxide synthase inhibitor) is an investigational medicine, being studied as a potential treatment for e-cigarette use.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- The use of electronic nicotine delivery systems, or e-cigarettes - colloquially referred to as "vaping" - in the United States has increased exponentially since their introduction to the US market in 2007. Prevalence of ever and current e-cigarette use is highest among teenagers and young adults with 16-28% of this population having reported vaping.
- Phase 1: an early, usually small safety study
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 24. Healthy volunteers may be eligible.
You may be able to join if
- 18-24 years old
- one of the following:
- have no history of e-cigarette use
- be a current e-cigarette user who has been using e-cigarettes for 6 months or longer
You likely can't join if
- history of cardiovascular, metabolic, and/or skin diseases
- body mass index \>30 kg/m2
- blood pressure ≥140 systolic and/or ≥ 90 diastolic
- current or history of tobacco cigarette use
- current antihypertensive or cholesterol-lowering medication
- current use of cannabis, marijuana, and/or other illegal substances
See the full eligibility criteria
- 18-24 years old
- one of the following:
- have no history of e-cigarette use
- be a current e-cigarette user who has been using e-cigarettes for 6 months or longer
- history of cardiovascular, metabolic, and/or skin diseases
- body mass index \>30 kg/m2
- blood pressure ≥140 systolic and/or ≥ 90 diastolic
- current or history of tobacco cigarette use
- current antihypertensive or cholesterol-lowering medication
- current use of cannabis, marijuana, and/or other illegal substances
- current use of stimulant drugs
- currently pregnant or breastfeeding
- allergy to materials used during the experiment (e.g. latex),
- known allergy to study drugs
- healthy control people will also be excluded if they have ever used e-cigarettes in the past
The study team makes the final eligibility decision.
Where it's taking place
- Iowa City, Iowa, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 24 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Iowa City, Iowa, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.