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New treatment option for Coarctation of Aorta
Official title A Study of Angiotensin-II Receptor Blocker on Cardiovascular Remodeling (VALUE Trial)
ClinicalTrials.gov ID: NCT06150560
What this study is testing
What is Losartan?
Losartan is an investigational medicine, given as an once-daily pill taken by mouth, being studied as a potential treatment for coarctation of aorta.
Also referred to as Cozaar.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- The purpose of this study is to evaluate the effectiveness and mechanism of action of Losartan in the treatment of coarctation of aorta.
- Phase 3: a large, late-stage study
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- B/S1 hypertension
- SBP 100-139 average based on 3 office measurements.
- Age 18 or Older
- Previous COA Repair
You likely can't join if
- Currently on beta blocker (BB) therapy
- Pregnancy/lactating
- eGFR\<30
- Hyperkalemia (serum potassium \>5.5mmol/L)
- Severe Aortic or Mitral valve stenosis or regurgitation
- Epicardial CAD diagnosis
See the full eligibility criteria
- B/S1 hypertension
- SBP 100-139 average based on 3 office measurements.
- Age 18 or Older
- Previous COA Repair
- Currently on beta blocker (BB) therapy
- Pregnancy/lactating
- eGFR\<30
- Hyperkalemia (serum potassium \>5.5mmol/L)
- Severe Aortic or Mitral valve stenosis or regurgitation
- Epicardial CAD diagnosis
- Received antihypertensive medications within the past year
The study team makes the final eligibility decision.
Where it's taking place
- Rochester, Minnesota, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Rochester, Minnesota, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.