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Tests treatment safety and results for Coronary Artery Bypass Grafting
Official title Safety and Efficacy of Remote Ischemic Conditioning for Patients Taking Off-pump Coronary Artery Bypass Grafting
ClinicalTrials.gov ID: NCT06141525
What this study is testing
- What it's testing
- Remote ischemic conditioning (RIC) is the process of repeated ischemia and reperfusion in the peripheral vessels, which is proved in reducing IRI in vital organs. This IMPROVE trial plans to enroll 648 patients who are diagnosed with coronary artery disease and are going to take off-pump CABG in five centers in China, to access whether RIC can and improve short-term prognosis.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 70
You may be able to join if
- Diagnosed with coronary artery disease and require off-pump CABG surgery.
- Between 18 and 75 years old;
- Normal left ventricular systolic function (ejection fraction \>40%) and left ventricular end-diastolic internal diameter (\<60 mm) in the cardiac...
- No or mild heart valve and great vessel abnormalities which do not require surgical intervention;
- Participants or their authorized relatives agree to participate in the clinical trial and sign the informed consent.
You likely can't join if
- Severe tissue injuries.
- Myalgia, fractures and other peripheral vascular lesions.
- Bypass graft being the radial artery.
- Stenosis or severe malformations of the subclavian, jugular and femoral arteries and veins.
- Previous vagus nerve trunk dissection or vagus nerve block surgery.
- Other surgical operations at the same time.
See the full eligibility criteria
- Diagnosed with coronary artery disease and require off-pump CABG surgery.
- Between 18 and 75 years old;
- Normal left ventricular systolic function (ejection fraction \>40%) and left ventricular end-diastolic internal diameter (\<60 mm) in the cardiac ultrasound tests;
- No or mild heart valve and great vessel abnormalities which do not require surgical intervention;
- Participants or their authorized relatives agree to participate in the clinical trial and sign the informed consent.
- Severe tissue injuries.
- Myalgia, fractures and other peripheral vascular lesions.
- Bypass graft being the radial artery.
- Stenosis or severe malformations of the subclavian, jugular and femoral arteries and veins.
- Previous vagus nerve trunk dissection or vagus nerve block surgery.
- Other surgical operations at the same time.
- Patients with pre-existing severe cardiac insufficiency, acute coronary syndromes, malignant hypertension and cardiogenic shock.
- Severe coagulation abnormality or severe anemia.
- Severe mental disorder.
- Malignant tumors.
- Pregnant or lactating.
- Increased risk of treatment for patients, according to investigators.
- Refuse to sign the informed consent form.
The study team makes the final eligibility decision.
Where it's taking place
- Xi'an, Shaanxi, China
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 70 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Xi'an, Shaanxi, China. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.