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New treatment option for Poliomyelitis
Official title Study of Trivalent and Bivalent (Types 1 & 2) Novel Oral Poliomyelitis Vaccines
ClinicalTrials.gov ID: NCT06137664
What this study is testing
What is Novel oral poliomyelitis vaccine type 1 (nOPV1)?
Novel oral poliomyelitis vaccine type 1 (nOPV1) is an investigational medicine, given as a pill taken by mouth, being studied as a potential treatment for poliomyelitis.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- The main objectives of this study are to : evaluate the safety and tolerability of trivalent novel oral poliovirus vaccines (tnOPV) in healthy adults, young children, and neonates, relative to those receiving control vaccines; evaluate the safety and tolerability of combined novel oral poliovirus vaccine type 1 (nOPV1) + novel oral poliovirus vaccine type 2 (nOPV2) in neonates, relative to those receiving the bivalent (types 1 and 3) oral poliovirus vaccine (bOPV) control. compare type-specific cumulative seroconversion rates of poliovirus neutralizing antibody (NAb) titers, among all tnOPV dose combinations, following 4 vaccinations in healthy neonates; evaluate the type-specific cumulative seroconversion rate of poliovirus NAb titers among healthy neonates following 4 doses of combined nOPV1+nOPV2.
- Phase 2: a mid-size study of how well it works
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 0 to 45. Healthy volunteers may be eligible.
You may be able to join if
- for all participants:
- Healthy, as defined by the absence of any clinically significant medical condition or congenital anomaly as determined by medical history, physical...
- Participant or parent of the participant is willing and able to provide written informed consent prior to performance of any study-specific procedure.
- Resides and plans to remain in study area and participants and parent, when applicable, understands and is able and willing to adhere to all study...
- Males or females, from 18 to 45 years of age (inclusive) at the time of enrollment.
You likely can't join if
- Exclusion Criteria for all participants (unless otherwise specified):
- Presence of anyone under 10 years of age in the participant's household (living in the same house or apartment unit) who does not have complete "age...
- A known allergy, hypersensitivity, or intolerance to any components of the study vaccines, including all macrolide and aminoglycoside antibiotics...
- Any self-reported known or suspected immunosuppressive or immunodeficiency condition (including HIV infection) in the participant or household member...
- Receipt of any immune-modifying or immunosuppressant drugs within 6 months prior to the first study vaccine dose or planned use during the study.
- Any known or suspected bleeding disorder in the participant that would pose a risk to venipuncture or intramuscular injection.
See the full eligibility criteria
Who can join
- for all participants:
- Healthy, as defined by the absence of any clinically significant medical condition or congenital anomaly as determined by medical history, physical examination, and clinical assessment of the investigator.
- Participant or parent of the participant is willing and able to provide written informed consent prior to performance of any study-specific procedure.
- Resides and plans to remain in study area and participants and parent, when applicable, understands and is able and willing to adhere to all study visits and procedures (as evidenced by a signed informed consent form...
- Males or females, from 18 to 45 years of age (inclusive) at the time of enrollment.
- If female and of childbearing potential\ , not breastfeeding and not pregnant (based on a negative urine pregnancy test at screening and a negative urine pregnancy test during the 24 hours prior to any study vaccination...
- Born and raised in Bangladesh in 1990 or later; if born before 1990 or not born and raised in Bangladesh, has documentation of a complete poliomyelitis immunization series containing OPV or IPV. for Cohort 2...
- Male or female child from 1 to less than 5 years of age at the time of enrollment (from the first birthday up to the day prior to the fifth birthday).
- Based on documentation, previously received a 3 or 4 dose primary poliomyelitis immunization series containing bOPV ± IPV, with last dose received more than 3 months prior to initial study vaccination. for Cohort 3...
- Male or female newborn neonate (day of birth+ 3-day window), at the time of initial study vaccination.
- Prior to study vaccination has received no doses of IPV or OPV or rotavirus vaccine, based upon documentation or parental history.
- Agreement to receive polio EPI vaccines under a modified schedule.
What rules you out
- Exclusion Criteria for all participants (unless otherwise specified):
- Presence of anyone under 10 years of age in the participant's household (living in the same house or apartment unit) who does not have complete "age appropriate" vaccination status with respect to poliovirus vaccines...
- A known allergy, hypersensitivity, or intolerance to any components of the study vaccines, including all macrolide and aminoglycoside antibiotics (e.g., erythromycin and kanamycin).
- Any self-reported known or suspected immunosuppressive or immunodeficiency condition (including HIV infection) in the participant or household member (living under the same roof/in the same building rather than in the...
- Receipt of any immune-modifying or immunosuppressant drugs within 6 months prior to the first study vaccine dose or planned use during the study.
- Any known or suspected bleeding disorder in the participant that would pose a risk to venipuncture or intramuscular injection.
- Moderate or severe (grade ≥ 2) acute illness including vomiting, diarrhea at the time of enrollment/first study vaccination - temporary exclusion.
- Presence of fever within the 72 hours of the day of enrollment/first study vaccination (oral temperature ≥38.0˚C for Cohort 1; axillary temperature ≥37.5˚C for Cohorts 2 and 3) or any antipyretic use within past 24...
- Evidence of a clinically significant major congenital or genetic defect as judged by the investigator.
- History of chronic administration (defined as more than 14 days) of immunosuppressant medications, including corticosteroids (\> 0.5mg/kg/day or 20 mg/day of prednisolone (or equivalent) within 6 months prior to first...
- Participation in another investigational product (drug or vaccine, including prior polio vaccine trials) clinical trial within 30 days prior to entry in this study or receipt of any such investigational product other...
- Receipt of transfusion of any blood product or immunoglobulins within 12 months prior to the first administration of study vaccine or planned during the study period.
- Participant or parent, when applicable, has any condition that in the opinion of the investigator would increase the participant's health risks in study participation or would increase the risk of not achieving the...
- Receipt of polio vaccine within 12 months before the start of the study.
- Having Crohn's disease or ulcerative colitis or having had major surgery of the gastrointestinal tract involving significant loss or resection of the bowel.
- Will have household direct or close professional contact during the study with pregnant women.
- Will have household direct or close professional (e.g., neonatal nurses) contact during the study with children less than 2 years of age or with individuals who are encopretic (i.e., soiling of underwear with stool by...
- Will have professional handling of food, catering, or food production activities during the study. Exclusion Criteria for Cohort 2 participants:
- Any participating children attending day care or pre-school during their participation in the study until one month after their last study vaccine administration.
- Presence of severe malnutrition [weight-for-length/height z-score \<-3SD median (per WHO published child growth standards)]-temporary exclusion if marginal and subsequently gains weight. Exclusion Criteria for Cohort 3...
- Low birth weight (LBW) in newborn participants which is defined as a birth weight of less than 2500 g (up to and including 2499 g) at the time of birth or by the time of enrollment
- Premature birth (less than 37 weeks gestation).
- From multiple birth (due to increased risk of OPV transmissions between siblings).
The study team makes the final eligibility decision.
Where it's taking place
- Dhaka, Bangladesh
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 0 days to 45 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Dhaka, Bangladesh. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.