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New treatment option for Pneumonia, Viral
Official title Acyclovir in Ventilated Patients With Pneumonia and HSV-1 in BAL
ClinicalTrials.gov ID: NCT06134492
What this study is testing
What is Acyclovir?
Acyclovir is an investigational medicine, given as an infusion into a vein, being studied as a potential treatment for pneumonia, viral.
Also referred to as Aciclovir.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- Almost 90 out of 100 people carry herpes simplex viruses (HSV). Once a person has been infected with the herpes viruses, he or she can't get rid of them for the rest of her/his life.
- Phase 3: a large, late-stage study
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- ≥ 18 years
- need for invasive or non-invasive respiratory support
- PCR HSV-1 detection in BAL (≥ 10\^3 copies/ml)
- Pneumonia (community or healthcare acquired, incl. ventilator-associated pneumonia)
- declaration of consent by the patient or legal representative
You likely can't join if
- History of hypersensitivity to acyclovir or valacyclovir or other components of the investigational product.
- Pregnancy/Lactation
- Simultaneous participation in another treatment clinical trial
- Decision to withhold life-sustaining therapies
- Use of a virostatic agent (i.v. or p. os) with activity against herpes simplex (acyclovir, valacyclovir, famciclovir/penciclovir, brivudine...
- Solid organ transplantation, stem cell transplantation
See the full eligibility criteria
- ≥ 18 years
- need for invasive or non-invasive respiratory support
- PCR HSV-1 detection in BAL (≥ 10\^3 copies/ml)
- Pneumonia (community or healthcare acquired, incl. ventilator-associated pneumonia)
- declaration of consent by the patient or legal representative
- History of hypersensitivity to acyclovir or valacyclovir or other components of the investigational product.
- Pregnancy/Lactation
- Simultaneous participation in another treatment clinical trial
- Decision to withhold life-sustaining therapies
- Use of a virostatic agent (i.v. or p. os) with activity against herpes simplex (acyclovir, valacyclovir, famciclovir/penciclovir, brivudine, cidofovir, foscarnet) for therapeutic or prophylactic reasons at the time of...
- Solid organ transplantation, stem cell transplantation
- Neutropenia (absolute neutrophil count \<1500/μl (\<1.5 × 109 /l)
- Previous study participation in HerpMV
The study team makes the final eligibility decision.
Where it's taking place
- Freiburg im Breisgau, Baden-Wurttemberg, Germany
- Heidelberg, Baden-Wurttemberg, Germany
- Tübingen, Baden-Wurttemberg, Germany
- Augsburg, Bavaria, Germany
- München, Bavaria, Germany
- Nuremberg, Bavaria, Germany
- Regensburg, Bavaria, Germany
- Rosenheim, Bavaria, Germany
- Herne, Nordreihn-Westfalen, Germany
- Bielefeld, North Rhine-Westphalia, Germany
- Bonn, North Rhine-Westphalia, Germany
- Cologne, North Rhine-Westphalia, Germany
- Düsseldorf, North Rhine-Westphalia, Germany
- Essen, North Rhine-Westphalia, Germany
- Münster, North Rhine-Westphalia, Germany
- Dresden, Saxony, Germany
- Leipzig, Saxony, Germany
- Halle, Saxony-Anhalt, Germany
- Kiel, Schleswig-Holstein, Germany
- Lübeck, Schleswig-Holstein, Germany
+ 3 more site(s).
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Freiburg im Breisgau, Baden-Wurttemberg, Germany; Heidelberg, Baden-Wurttemberg, Germany; Tübingen, Baden-Wurttemberg, Germany; Augsburg, Bavaria, Germany; München, Bavaria, Germany; Nuremberg, Bavaria, Germany and 17 more location(s). Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.