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New treatment option for Locally Advanced Head and Neck Squamous Cell Carcinoma
Official title A Global Study of Volrustomig (MEDI5752) for Participants With Unresected Locally Advanced Head and Neck Squamous Cell Carcinoma Following Definitive Concurrent Chemoradiotherapy
ClinicalTrials.gov ID: NCT06129864
What this study is testing
What is volrustomig?
volrustomig is an investigational medicine, being studied as a potential treatment for locally advanced head and neck squamous cell carcinoma.
Also referred to as MEDI5752.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- The main purpose of this study is to assess the efficacy and safety of volrustomig compared to observation in participants with unresected locally advanced head and neck squamous cell carcinoma (LA-HNSCC) who have not progressed after receiving definitive concurrent chemoradiotherapy (cCRT).
- Phase 3: a large, late-stage study
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 130
You may be able to join if
- Histologically or cytologically documented locally advanced squamous cell carcinoma of the oropharynx, hypopharynx, oral cavity, or larynx with no...
- Confirmed unresected Stage III, Stage IVA or IVB according to the eighth edition of the American Joint Committee on Cancer (AJCC) staging manual...
- Participants will have completed definitive concurrent chemoradiotherapy (cCRT) with curative intent prior to randomization.
You likely can't join if
- Histologically/cytologically confirmed head and neck cancer of any other primary anatomic location in the head and neck not specified in the...
- Participants with any of the following:
- LA-HNSCC that was resected before definitive cCRT
- LA-HNSCC that was treated and is recurrent at the time of screening
- Participants who have received radiotherapy (RT) alone as definitive local therapy for LA-HNSCC.
The study team makes the final eligibility decision.
Where it's taking place
- Birmingham, Alabama, United States
- Phoenix, Arizona, United States
- Prescott Valley, Arizona, United States
- Springdale, Arkansas, United States
- Fountain Valley, California, United States
- Los Angeles, California, United States
- Orange, California, United States
- San Francisco, California, United States
- Santa Rosa, California, United States
- Whittier, California, United States
- Aurora, Colorado, United States
- Colorado Springs, Colorado, United States
- Lone Tree, Colorado, United States
- Washington D.C., District of Columbia, United States
- Fort Myers, Florida, United States
- Gainesville, Florida, United States
- Miami, Florida, United States
- Palm Bay, Florida, United States
- West Palm Beach, Florida, United States
- Niles, Illinois, United States
+ 245 more site(s).
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 130 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Birmingham, Alabama, United States; Phoenix, Arizona, United States; Prescott Valley, Arizona, United States; Springdale, Arkansas, United States; Fountain Valley, California, United States; Los Angeles, California, United States and 259 more location(s). Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.