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New treatment option for Chronic Pain
Official title Perioperative Vitamin C to Reduce Persistent Pain After Total Knee Arthroplasty
ClinicalTrials.gov ID: NCT06123715
What this study is testing
What is Vitamin C?
Vitamin C is an investigational medicine, given as an once-daily pill taken by mouth, being studied as a potential treatment for chronic pain.
Also referred to as Ascorbic Acid.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- Phase II Multicentre, pilot, parallel-group, blinded, 1:1 randomized controlled trial to determine the feasibility of conducting a larger definitive trail of using vitamin C to reduce persistent pain in patients undergoing total knee arthroplasty surgery.
- Phase 2: a mid-size study of how well it works
- You might receive a placebo (an inactive treatment) instead of the study drug, decided by chance. You may not know which one you got.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Patients \>18 years old
- Undergoing a unilateral or bilateral primary total knee arthroplasty for advanced osteoarthritis of the knee
You likely can't join if
- TKA for infection (septic joint), fracture, ankylosing spondylitis, lupus, or psoriatic arthritis
- History of kidney stones, acute or chronic renal failure, hemochromatosis, or glucose-6-phosphate deficiency
- Unlikely to comply with follow-up (e.g., no fixed address, plans to move out of town)
- Language difficulties that would impede valid completion of questionnaires
- Planned staged bilateral TKA
- Treating surgeon deems patient inappropriate for inclusion in trial
See the full eligibility criteria
- Patients \>18 years old
- Undergoing a unilateral or bilateral primary total knee arthroplasty for advanced osteoarthritis of the knee
- TKA for infection (septic joint), fracture, ankylosing spondylitis, lupus, or psoriatic arthritis
- History of kidney stones, acute or chronic renal failure, hemochromatosis, or glucose-6-phosphate deficiency
- Unlikely to comply with follow-up (e.g., no fixed address, plans to move out of town)
- Language difficulties that would impede valid completion of questionnaires
- Planned staged bilateral TKA
- Treating surgeon deems patient inappropriate for inclusion in trial
- Any allergy or sensitivity to milk
- Pregnant or planning to become pregnant during the study
The study team makes the final eligibility decision.
Where it's taking place
- Toronto, Ontario, Canada
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Toronto, Ontario, Canada. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.