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New treatment option for Knee Osteoarthritis
Official title Upper and Lower Extremity Exercise and Exercise-Induced Hypoalgesia in Knee Osteoarthritis
ClinicalTrials.gov ID: NCT06105788
What this study is testing
- What it's testing
- The objective of the study is to explore the effects of arm exercise (UE, arm ergometer) vs. leg exercise (LE, cycling ergometer) on exercise-induced hypoalgesia (EIH), central pain mechanisms and knee pain in people with knee osteoarthritis (OA).
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 45 to 90. Healthy volunteers may be eligible.
You may be able to join if
- Participants with knee OA (Target n=40) We will recruit participants with knee OA, using the National Institute for Health and Care Excellence's...
- age ≥45
- activity-related knee pain
- either no morning joint-related stiffness or stiffness that lasts ≤ 30 minutes.
- knee pain at least 4 on a 0-10 pain scale
You likely can't join if
- peripheral neuropathy or other sensation loss on the body sites for pain measurements (i.e., the wrist, knee, the forearm)
- use of medical devices electrically active (e.g., pacemaker)
- chronic use of opioids
- pregnant women
- serious and uncontrolled concomitant disease, including cardiovascular, nervous system, pulmonary, renal, hepatic, metabolic, hormonal, endocrine...
- rheumatoid arthritis, ankylosing spondylitis, and any neurological disorders that prevent the study procedure
See the full eligibility criteria
- Participants with knee OA (Target n=40) We will recruit participants with knee OA, using the National Institute for Health and Care Excellence's clinical diagnostic criteria, which does not require radiographs. The...
- age ≥45
- activity-related knee pain
- either no morning joint-related stiffness or stiffness that lasts ≤ 30 minutes.
- knee pain at least 4 on a 0-10 pain scale
- knee pain as a chief complaint if having multiple pain
- understand English
- peripheral neuropathy or other sensation loss on the body sites for pain measurements (i.e., the wrist, knee, the forearm)
- use of medical devices electrically active (e.g., pacemaker)
- chronic use of opioids
- pregnant women
- serious and uncontrolled concomitant disease, including cardiovascular, nervous system, pulmonary, renal, hepatic, metabolic, hormonal, endocrine, gastrointestinal or epileptic disease
- rheumatoid arthritis, ankylosing spondylitis, and any neurological disorders that prevent the study procedure
- cognitive impairment
- history of a knee replacement surgery
- inability to perform exercise due to severe pain or other symptoms
- any intervention procedures for knee pain in the last 3 months Inclusion and exclusion criteria for pain-free controls (Target n = 20) Pain-free controls are not having a pain-related medical condition. They have to...
The study team makes the final eligibility decision.
Where it's taking place
- El Paso, Texas, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 45 years to 90 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include El Paso, Texas, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.