BridgeMD
New treatment option for Sepsis
Official title Integrated Clinical Decision Support for Empiric Antibiotic Selection in Sepsis
ClinicalTrials.gov ID: NCT06103500
What this study is testing
- What it's testing
- As antibiotic resistance increases globally, it becomes more difficult to select empiric antibiotic therapy, particularly in patients with sepsis who stand to benefit from early adequate treatment. In particular it is difficult for clinicians to balance antibiotic stewardship principles (the need to avoid unnecessary prescribing of antibiotics that have an excessively broad spectrum of activity that favour resistance development) and under treatment.
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Admitted
- Age \>18 years old
- Newly started (within 24 hours of assessment for eligibility) on at least one of the following antibiotic(s): I. Vancomycin IV II. Linezolid III...
- Blood cultures ordered (within 12 hours before or after initiation of index antibiotics). Overall Exclusion:
- Pregnancy/breastfeeding
You likely can't join if
- Explanatory molecular test (e.g. legionella urinary antigen test, sars-cov-2 testing) within 72 hours prior to assessment.
- Receipt of antimicrobials (not chronic suppression or prophylaxis) in the prior 24-72 hours (except if started in the outpatient setting or ED prior...
- The index prescription is a continuation of an antibiotic given for suppressive chronic therapy or long-standing treatment of an established...
- Index antibiotics are peri-operative only or ordered for \<24 hours.
- Cystic fibrosis.
- Known to be enrolled in a trial that dictates antimicrobial selection.
See the full eligibility criteria
- Admitted
- Age \>18 years old
- Newly started (within 24 hours of assessment for eligibility) on at least one of the following antibiotic(s): I. Vancomycin IV II. Linezolid III. Daptomycin IV. Clindamycin V. Cefazolin VI. Cloxacillin VII. Ceftriaxone...
- Blood cultures ordered (within 12 hours before or after initiation of index antibiotics). Overall Exclusion:
- Pregnancy/breastfeeding
- Documented end-of-life (palliative) care and are/will not be receiving ongoing antibiotic treatment.
- Already enrolled in the trial.
- Positive clinical culture results (those with speciation) for the index infection (within 72 hours) already available prior to assessment. Blood cultures with any Gram-positives will be an exclusion. Other cultures that...
- Explanatory molecular test (e.g. legionella urinary antigen test, sars-cov-2 testing) within 72 hours prior to assessment.
- Receipt of antimicrobials (not chronic suppression or prophylaxis) in the prior 24-72 hours (except if started in the outpatient setting or ED prior to admission in the 24-72 hours).
- The index prescription is a continuation of an antibiotic given for suppressive chronic therapy or long-standing treatment of an established infection.
- Index antibiotics are peri-operative only or ordered for \<24 hours.
- Cystic fibrosis.
- Known to be enrolled in a trial that dictates antimicrobial selection.
- Not eligible for any of the algorithms.
The study team makes the final eligibility decision.
Where it's taking place
- Mississauga, Ontario, Canada
- Ottawa, Ontario, Canada
- Toronto, Ontario, Canada
Compensation & support
Compensation mentioned.
ClinicalTrials.gov doesn't provide a reliable structured field for payment or travel support - confirm details with the study team.
Questions & answers
Do participants get paid in this trial?
This study's listing includes signals that participants may be compensated or receive a stipend. Amounts vary and are set by the study team - confirm the details with them.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Mississauga, Ontario, Canada; Ottawa, Ontario, Canada; Toronto, Ontario, Canada. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.