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New treatment option for Salt-Sensitivity of Blood Pressure
Official title Forebrain Electroneutral Transporters in Salt-sensitive Hypertension: an MRI Study
ClinicalTrials.gov ID: NCT06094816
What this study is testing
What is Furosemide (Diuretic)?
Furosemide (Diuretic) is an investigational medicine, given as an infusion into a vein, being studied as a potential treatment for salt-sensitivity of blood pressure.
Also referred to as Lasix.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- The overall objective of this project is to identify the key salt-sensing regions of the brain and determine the underlying mechanism of sodium sensing. The investigators will assess how the brain responds to an acute increase of salt in the blood using MRI.
- Phase 4: studies an already-approved treatment
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 40 to 60. Healthy volunteers may be eligible.
You may be able to join if
- Age: \> 40 years or \< 60 years
- Blood pressure: \> 100/60 mmHg or \< 140/90 mmHg
- BMI: \> 18.5 kg/m2 or \< 35 kg/m2
- Serum potassium: \> 3.5 mmol/L or \< 5.5 mmol/L
- No history of cardiovascular, renal, metabolic, or neurological disease
You likely can't join if
- Age: \ 60 years
- Blood pressure: \ 140/90 mmHg
- BMI: \ 30 kg/m2
- Serum potassium: \ 5.5 mmol/L
- Abnormal ECG
- History of - cardiovascular, cancer, metabolic, respiratory, renal disease
See the full eligibility criteria
- Age: \> 40 years or \< 60 years
- Blood pressure: \> 100/60 mmHg or \< 140/90 mmHg
- BMI: \> 18.5 kg/m2 or \< 35 kg/m2
- Serum potassium: \> 3.5 mmol/L or \< 5.5 mmol/L
- No history of cardiovascular, renal, metabolic, or neurological disease
- Age: \ 60 years
- Blood pressure: \ 140/90 mmHg
- BMI: \ 30 kg/m2
- Serum potassium: \ 5.5 mmol/L
- Abnormal ECG
- History of - cardiovascular, cancer, metabolic, respiratory, renal disease
- Hormone replacement therapy
- Current tobacco or nicotine use
- Pregnant or nursing mothers
- Major brain injury (concussions do not count)
- Clinically diagnosed psychiatric or neurological disorder
- Clinically diagnosed anxiety or depression
- Psychiatric, neurological, anxiety or depression medications
- Hypertension medications
- Sulfonamide drug allergy
- Contra-indications to MRI (implants, metal, etc)
- Claustrophobia
The study team makes the final eligibility decision.
Where it's taking place
- Newark, Delaware, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 40 years to 60 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Newark, Delaware, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.